Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy

doi:10.1016/j.jconrel.2020.01.002

	Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy
	Zou, Qianli 1; Chang, Rui 1,2; Xing, Ruirui 1; Yuan, Chengqian 1; Yan, Xuehai 1,2,3
刊名	JOURNAL OF CONTROLLED RELEASE
	2020-03-10
卷号	319 页码:344-351
关键词	Bola-dipeptide 5-aminolevulinic acid Hydrogel Self-assembly Photodynamic therapy
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2020.01.002
英文摘要	Supramolecular peptide materials have attracted increasing attention due to their natural biological origin and versatile applications. However, it is often challenging to control and modulate the self-assembly of peptides (especially short peptides) for constructing hydrogels with tunable mechanical properties and adaptive injectability toward biomedical applications. Here, we report a supramolecular strategy for forming robust and injectable hydrogels based on the self-assembly of a rationally designed bola-dipeptide. The self-assembled hydrogels exhibit versatile functionalities, including flow under shear stress, good recovery properties, and easy encapsulation of hydrophilic prodrugs. The prodrug-loaded hydrogels show sustained release profiles, inhibited nontargeted leakage, and enhanced localized prodrug conversion, leading to highly efficient photodynamic tumor ablation. Hence, the supramolecular strategy is promising for the rational construction of injectable hydrogels toward targeted and sustained prodrug conversion and tumor therapy.
资助项目	National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS关键词	5-AMINOLEVULINIC ACID ; BETA-SHEET
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000515538300026
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39642]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zou, Qianli,Chang, Rui,Xing, Ruirui,et al. Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,319:344-351.
APA	Zou, Qianli,Chang, Rui,Xing, Ruirui,Yuan, Chengqian,&Yan, Xuehai.(2020).Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy.JOURNAL OF CONTROLLED RELEASE,319,344-351.
MLA	Zou, Qianli,et al."Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy".JOURNAL OF CONTROLLED RELEASE 319(2020):344-351.