NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy

doi:10.1002/adma.201907855

	NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy
	Xi, Dongmei 1; Xiao, Ming 1; Cao, Jianfang 1; Zhao, Luyang 2; Xu, Ning 1; Long, Saran 1; Fan, Jiangli 1; Shao, Kun 1; Sun, Wen 1; Yan, Xuehai 2
刊名	ADVANCED MATERIALS
	2020-02-05
页码	8
关键词	barrier-free rotation NIR light photothermal therapy polymeric nanoparticles safe intensity light
ISSN号	0935-9648
DOI	10.1002/adma.201907855
英文摘要	Traditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a -CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the -CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of -CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm(-2), 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment.
资助项目	National Natural Science Foundation of China[21808028] ; National Natural Science Foundation of China[21576037] ; National Natural Science Foundation of China[21421005] ; Science and Technology Foundation of Liaoning Province[2019-BS-047] ; Fundamental Research Funds for the Central Universities[2018011013]
WOS关键词	AGGREGATION ; SQUARAINE ; VESICLES ; SENSOR ; AGENT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000511035300001
资助机构	National Natural Science Foundation of China ; Science and Technology Foundation of Liaoning Province ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39260]
专题	中国科学院过程工程研究所
通讯作者	Sun, Wen; Peng, Xiaojun
作者单位	1.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xi, Dongmei,Xiao, Ming,Cao, Jianfang,et al. NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy[J]. ADVANCED MATERIALS,2020:8.
APA	Xi, Dongmei.,Xiao, Ming.,Cao, Jianfang.,Zhao, Luyang.,Xu, Ning.,...&Peng, Xiaojun.(2020).NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy.ADVANCED MATERIALS,8.
MLA	Xi, Dongmei,et al."NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy".ADVANCED MATERIALS (2020):8.