Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly

doi:10.1002/smll.201907309

	Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly
	Song, Jingwen 2,5; Yuan, Chengqian 2; Jiao, Tifeng 5; Xing, Ruirui 2; Yang, Mengyao 1,2; Adams, Dave J.3; Yan, Xuehai 1,2,4
刊名	SMALL
	2020-02-01
卷号	16 期号:8 页码:10
关键词	amino acids antimicrobial biometallohydrogels broad-spectrum coordinated self-assembly
ISSN号	1613-6810
DOI	10.1002/smll.201907309
英文摘要	There is a real need for new antibiotics against self-evolving bacteria. One option is to use biofriendly broad-spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug-resistant microbes. Whilst appealing, there are currently limited options. Herein, broad-spectrum antimicrobial biometallohydrogels based on the self-assembly and local mineralization of Ag+-coordinated Fmoc-amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self-assembly toward a broad range of biomedical applications.
资助项目	National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; EPSRC[EP/L021978/1]
WOS关键词	STAPHYLOCOCCUS-AUREUS ; CATIONIC POLYMERS ; SILVER ; PEPTIDES ; HYDROGEL ; NANOARCHITECTONICS ; NANOSTRUCTURES ; NANOPARTICLES ; NANOCLUSTERS ; ANTIBIOTICS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000511243900001
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; EPSRC
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39211]
专题	中国科学院过程工程研究所
通讯作者	Jiao, Tifeng; Adams, Dave J.; Yan, Xuehai
作者单位	1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China 5.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Song, Jingwen,Yuan, Chengqian,Jiao, Tifeng,et al. Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly[J]. SMALL,2020,16(8):10.
APA	Song, Jingwen.,Yuan, Chengqian.,Jiao, Tifeng.,Xing, Ruirui.,Yang, Mengyao.,...&Yan, Xuehai.(2020).Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly.SMALL,16(8),10.
MLA	Song, Jingwen,et al."Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly".SMALL 16.8(2020):10.