Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy

doi:10.1002/smll.201905326

	Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy
	Sun, Haifeng 1,2; Chang, Rui 1,3; Zou, Qianli 1; Xing, Ruirui 1; Qi, Wei 2; Yan, Xuehai 1,3,4
刊名	SMALL
	2019-10-28
页码	7
关键词	albumin nanodrugs pheophorbide a photothermal therapy self-assembly
ISSN号	1613-6810
DOI	10.1002/smll.201905326
英文摘要	Supramolecular protein nanodrugs provide opportunities for improving antitumor therapeutic efficiency and lowering toxicity. However, protein nanodrugs that have robust structural stability and enhanced therapeutic efficiency are still in infancy. In this study, photothermal protein nanodrugs are constructed through a supramolecular approach along with heating by using proteins, photosensitizers, and metal ions as the building blocks. The metal coordination and heating improve not only the structural stability but also photothermal performance of the resulting nanodrugs. By virtue of the first integration of coordination- and heating-enhanced photothermal effects, the nanodrugs show superior photothermal conversion efficiency, enhanced tumor accumulation, and improved tumor inhibition. Metal coordination and heating are versatile to be applied for various protein nanodrugs. Hence, this study provides insights for the construction of highly efficient photothermal nanodrugs and thus will be beneficial to precision theranostics.
资助项目	National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	SERUM-ALBUMIN NANOPARTICLES ; CANCER-THERAPY ; PHOTODYNAMIC THERAPY ; THERMAL-DENATURATION ; IN-VITRO ; DELIVERY ; HYDROPHOBICITY ; THERANOSTICS ; PHEOPHORBIDE ; GRAPHENE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000492739800001
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39059]
专题	中国科学院过程工程研究所
通讯作者	Zou, Qianli; Qi, Wei; Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Sun, Haifeng,Chang, Rui,Zou, Qianli,et al. Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy[J]. SMALL,2019:7.
APA	Sun, Haifeng,Chang, Rui,Zou, Qianli,Xing, Ruirui,Qi, Wei,&Yan, Xuehai.(2019).Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy.SMALL,7.
MLA	Sun, Haifeng,et al."Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy".SMALL (2019):7.