Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy

doi:10.1016/j.jcis.2019.09.049

	Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy
	Yang, Mengyao 2,3; Yuan, Chengqian 2; Shen, Guizhi 2; Chang, Rui 2,3; Xing, Ruirui 2; Yan, Xuehai 1,2,3
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2019-12-01
卷号	557 页码:458-464
关键词	Cyclic dipeptide Nanoribbon Self-assembly Dye Tumor therapy
ISSN号	0021-9797
DOI	10.1016/j.jcis.2019.09.049
英文摘要	Cyclic dipeptides (CDPs), the smallest naturally occurring cyclic peptides, have attracted tremendous attention due to their exceptional biological and pharmacological activities such as antitumor, antimicrobial, and immune regulation. However, controlled fabrication of CDPs nanostructures to address the problem of poor aqueous solubility and low bioavailability existing in therapeutic application is still in challenging, due to their remarkable structural rigidity and superior hydrogen-bonding-forming capability. Herein, a simple but robust and universal strategy for the construction of CDP nanoribbons based on the amphiphilic dye-mediated hydrophobic self-assembly is presented. The amphiphilic dyes not only provide the robust hydrophobic interaction for the formation of CDP nanoribbons but also offer enough electrostatic repulsion forces to stabilize the formed assemblies. Moreover, the introduction of functional dyes endows the assembled CDP nanoribbons multiple benign therapeutic features, including adjustable shape and size, improved bioavailability, as well as preferable cellular uptake and biodistribution, thereby enhanced chemotherapy efficacy in vitro and in vivo. The strategy developed based on the dye-mediated self-assembly provides a promising way to rationally design water-insoluble bioactive CDPs for therapeutic applications. (C) 2019 Elsevier Inc. All rights reserved.
资助项目	National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	BUILDING-BLOCKS ; RATIONAL DESIGN ; NANOSTRUCTURES ; TRANSFORMATION ; AMPHIPHILES ; DERIVATIVES ; FABRICATION ; PEPTIDES ; GELATION ; FORCE
WOS研究方向	Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000494056200045
资助机构	National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39026]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai
作者单位	1.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,et al. Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,557:458-464.
APA	Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,557,458-464.
MLA	Yang, Mengyao,et al."Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 557(2019):458-464.