Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice

doi:10.1093/femsle/fnz153

	Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice
	Zhai, Shixiang 3,4; Qin, Song 4; Li, Lili 4; Zhu, Limeng 2,3; Zou, Zhiqiang 1; Wang, Li 1
刊名	FEMS MICROBIOLOGY LETTERS
	2019-07-01
卷号	366 期号:13 页码:7
关键词	butyrate gut microbiota inflammation endotoxin SCFAs
ISSN号	0378-1097
DOI	10.1093/femsle/fnz153
英文摘要	Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim of this study was to investigate how butyrate impacts gut microbiota and immunity response in high-fat diet-fed mice. Gut microbial analysis exhibited that butyrate intervention increased short-chain fatty acids (SCFAs)-producing bacteria and decreased pathogenic bacteria, such as endotoxin-secreting bacteria. Our result also demonstrated that butyrate intervention enhanced fecal SCFAs concentrations, and inhibited endotoxin levels in feces and serum. Correlation analysis indicated positive relation between endotoxin level and Desulfovibrionaceae abundance. Furthermore, butyrate intervention inhibited expressions of IL-1 beta, IL-6 and MCP1/CCL2 in liver, as well as TLR4 in adipose tissue. Apart from inhibiting expressions of proinflammatory cytokines, butyrate exerted anti-inflammation effect through selectively modulating gut microbiota, such as increasing SCFAs-producing bacteria and decreasing endotoxin-secreting bacteria, as well as via regulating levels of microbiota-dependent metabolites and components, such as SCFAs and endotoxin.
资助项目	Youth Innovation Promotion Association of Chinese Academy of Sciences[2018246] ; National Key Research and Development Program of China[2017YFC0506200] ; National Innovation and Development of Marine Economy Demonstration Area of the City[2016496]
WOS关键词	OBESITY ; ACIDS
WOS研究方向	Microbiology
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000493065400004
资助机构	Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Innovation and Development of Marine Economy Demonstration Area of the City
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39006]
专题	中国科学院过程工程研究所
通讯作者	Li, Lili
作者单位	1.Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhai, Shixiang,Qin, Song,Li, Lili,et al. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice[J]. FEMS MICROBIOLOGY LETTERS,2019,366(13):7.
APA	Zhai, Shixiang,Qin, Song,Li, Lili,Zhu, Limeng,Zou, Zhiqiang,&Wang, Li.(2019).Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice.FEMS MICROBIOLOGY LETTERS,366(13),7.
MLA	Zhai, Shixiang,et al."Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice".FEMS MICROBIOLOGY LETTERS 366.13(2019):7.