Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting

doi:10.1021/acsami.9b13905

	Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting
	Jian, Honglei 2; Wang, Meiyue 2; Dong, Qjanqian 2; Li, Jieling 2; Wang, Anhe 2; Li, Xin 2; Ren, Peng 2; Bai, Shuo 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-12-18
卷号	11 期号:50 页码:46419-46426
关键词	peptide hydrogel 3D bioprinting mechanical property tumor spheroid
ISSN号	1944-8244
DOI	10.1021/acsami.9b13905
英文摘要	Supramolecular hydrogels self-assembled from short peptides have shown great potential as biomimetic extracellular matrices with controllable properties designed at the molecular level. However, their weak mechanical strength still remains a big challenge for 3D bioprinting. Herein, two oppositely charged dipeptides are designed and used as bioinks in a "layer-by-layer" alternative bioprinting strategy. During printing, in situ gelation is achieved by electrostatic interactions between two dipeptides without additional cross-linking procedures. The binary hydrogels have tunable mechanical properties with elastic moduli ranging from 4 to 62 kPa and controllable biodegradability from days to weeks, which can ideally mimic the natural environment of a variety of cell types. It is demonstrated that the hydrogel scaffold enables the formation, growth, and natural release of HepaRG spheroids with sizes up to millimeters. This strategy may be suitable to develop a series of new bioink materials based on peptides and other supramolecular polymers for 3D bioprinting.
资助项目	National Natural Science Foundation of China[21774132] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020206]
WOS关键词	BETA-SHEET ; CELL-CULTURE ; PEPTIDE ; BIOINK ; SCAFFOLDS ; STIFFNESS ; DESIGN ; CHARGE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000503918300003
资助机构	National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/38586]
专题	中国科学院过程工程研究所
通讯作者	Bai, Shuo
作者单位	1.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Jian, Honglei,Wang, Meiyue,Dong, Qjanqian,et al. Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(50):46419-46426.
APA	Jian, Honglei.,Wang, Meiyue.,Dong, Qjanqian.,Li, Jieling.,Wang, Anhe.,...&Bai, Shuo.(2019).Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting.ACS APPLIED MATERIALS & INTERFACES,11(50),46419-46426.
MLA	Jian, Honglei,et al."Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting".ACS APPLIED MATERIALS & INTERFACES 11.50(2019):46419-46426.