Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy

doi:10.1021/acsami.9b13966

	Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy
	Liu, Yamei 1,4,5; Shen, Guizhi 1; Zhao, Luyang 1; Zou, Qianli 1; Jiao, Tifeng 4,5; Yan, Xuehai 1,2,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-11-13
卷号	11 期号:45 页码:41898-41905
关键词	photothermal nanoparticle peptide genipin covalent assembly tumor therapy
ISSN号	1944-8244
DOI	10.1021/acsami.9b13966
英文摘要	Photothermal nanodrugs based on biomolecules are critically important for advancing photothermal therapy (PTT). However, constructing photothermal nano drugs from biomolecules is highly challenging because most biomolecules are inherently nonpigmented. Herein, we synthesize well-defined, uniform photothermal nanodrugs through a covalent assembly approach by using nonpigmented peptides and iridoids as building blocks. The resulting photothermal nanodrugs show broad absorption from the UV to the near-infrared region, high photothermal conversion efficiency along with robust photostability, and selective tumor accumulation, leading to highly efficient tumor ablation via PTT. This work represents the first example of photothermal nanodrugs that can be constructed by using nonpigmented biomolecules as building blocks and thus will conceivably promote the preclinical evaluation and clinical translation of PTT.
资助项目	National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS关键词	PHOTODYNAMIC THERAPY ; CROSS-LINKING ; NANOPARTICLES ; PHOTOSENSITIZERS ; CAPABILITIES ; NANOSPHERES ; GENIPIN ; DESIGN
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000497263600007
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/38298]
专题	中国科学院过程工程研究所
通讯作者	Zou, Qianli; Jiao, Tifeng; Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China 4.Yanshan Univ, Sch Environm & Chem Engn, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China 5.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yamei,Shen, Guizhi,Zhao, Luyang,et al. Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(45):41898-41905.
APA	Liu, Yamei,Shen, Guizhi,Zhao, Luyang,Zou, Qianli,Jiao, Tifeng,&Yan, Xuehai.(2019).Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(45),41898-41905.
MLA	Liu, Yamei,et al."Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.45(2019):41898-41905.