Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in surface water

	Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in surface water
	Wang, Zhenglu; Xu, Zeqiong; Wu, Yuexia; Zhang, Zhaobin; Li, Xiqing
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2020
卷号	393
英文摘要	This work for the first time investigated the bioconcentration factor (BCF), toxicity, and eco-risk of KET using adult medaka fish (Oryzias latipes) as model organism after exposure at environmental concentrations (0.05-0.5 mu g L-1) and higher levels (5-100 mu g L-1) for 90 days. The BCF of KET was approximately 1.07- to 10.94- folds. The behavioral functions, including swimming properties, feeding rate, and food preference, were significantly impacted by KET (>= 0.05 mu g L-1). After 90-days exposure, KET induced histological abnormalities in liver and kidney tissue at 0.1 and 0.2 mu g L-1, respectively. Additionally, the condition factor, hepatic-somatic index (HSI), and nephric-somatic index (NSI) of medaka were markedly impacted by KET treatment at 0.5, 0.5, and 0.1 mu g L-1, respectively. Morphological inflammation (i.e., haemorrhage and erosion) in the fish body was observed exposed to KET, and the EC10 value was 0.407 mu g L-1. Alterations in the expressions of genes (i.e., cacna1c, oxtr, erk1, and c-fos) and proteins (i.e., OXT and PKA), involved in in calcium ion channels induced by KET, could partly elucidate the underlying mechanism of the toxicity. The inflammatory risk to fish posed by KET in some rivers in southern China was at high level, suggesting the long-term concentration monitoring was required.
内容类型	期刊论文
源URL	[http://159.226.73.51/handle/332005/20229]
专题	中国科学院南京地理与湖泊研究所
推荐引用方式 GB/T 7714	Wang, Zhenglu,Xu, Zeqiong,Wu, Yuexia,et al. Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in surface water[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,393.
APA	Wang, Zhenglu,Xu, Zeqiong,Wu, Yuexia,Zhang, Zhaobin,&Li, Xiqing.(2020).Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in surface water.JOURNAL OF HAZARDOUS MATERIALS,393.
MLA	Wang, Zhenglu,et al."Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in surface water".JOURNAL OF HAZARDOUS MATERIALS 393(2020).