Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes

doi:10.1002/ajoc.202000723

CORC > 青海盐湖研究所 > 中国科学院青海盐湖研究所 > 盐湖资源与化学实验室

	Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes
	Wu, Wen-Feng; Lin, Jin-Hong; Xiao, Ji-Chang; Cao, Yu-Cai; Ma, Yanfang
刊名	ASIAN JOURNAL OF ORGANIC CHEMISTRY
	2021-03
卷号	10 期号:3 页码:485-495
ISSN号	2193-5807
DOI	10.1002/ajoc.202000723
英文摘要	CF3- or HCF2-substituted cyclopropanes are of great interest in pharmaceutical chemistry and agrochemistry, and thus significant efforts have been directed towards the development of efficient methods for the installation of these motifs. This Minireview summarizes recent efforts for the construction of CF3- or HCF2-substituted cyclopropanes. CF3-cyclopropanes are usually synthesized by a transition-metal-catalyzed cyclopropanation of alkenes with a trifluoromethylcarbene generated in situ from a diazocompound, CF3CHN2 or CF3C(Ar)N-2. The synthesis of HCF2-cyclopropanes remains largely unexplored. Some difluoromethylcarbene reagents have been developed, such as HCF2CHN2, Ph2S+CH2CF2H TfO-, and difluoroacetaldehyde N-triftosylhydrazone (DFHZ-Tfs), and cyclopropanation of alkenes with these reagents could also occur by transition metal catalysis. These protocols may find great utility in the synthesis of biologically active molecules.
内容类型	期刊论文
源URL	[http://ir.isl.ac.cn/handle/363002/34333]
专题	青海盐湖研究所_盐湖资源与化学实验室
推荐引用方式 GB/T 7714	Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,et al. Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2021,10(3):485-495.
APA	Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,Cao, Yu-Cai,&Ma, Yanfang.(2021).Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes.ASIAN JOURNAL OF ORGANIC CHEMISTRY,10(3),485-495.
MLA	Wu, Wen-Feng,et al."Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes".ASIAN JOURNAL OF ORGANIC CHEMISTRY 10.3(2021):485-495.