Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.

doi:10.1016/S1875-5364(21)60091-2

	Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.
	Wu Jie-Wei 1,2,3; Tang Chun-Ping 2,3; Yao Sheng 2,3; Ke Chang-Qiang 2,3; Ye Yang 2,3,4
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2021-11-01
卷号	19 期号:11 页码:868-873
关键词	Sesquiterpenoid dimer Carpesium abrotanoides L. Carabrane sesquiterpenoid Dicarabrol B Dicarabrol C 11R-hydroxycarabrol
ISSN号	2095-6975
DOI	10.1016/S1875-5364(21)60091-2
通讯作者	Ye Yang(yye@simm.ac.cn)
英文摘要	Dicarabrols B and C (1 and 2), two new carabrane sesquiterpenoid dimers, along with one new carabrane sesquiterpenoid (3) were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. Dicarabrol B possesses a novel C-30 skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties, while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule. Dicarabrol C exhibited potent inhibitory effects on HL-60 cells with an IC50 value of 3.7 mu mol.L-1.
资助项目	China National Key RD Program[2017YFE0195100] ; China National Key RD Program[2018YFC1707000] ; National Natural Science Foundation of China[21920102003] ; National Natural Science Foundation of China[81903485]
WOS关键词	LACTONES ; CYTOTOXICITY ; DIMERS
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000723753700007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/299226]
专题	中国科学院上海药物研究所
通讯作者	Ye Yang
作者单位	1.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu Jie-Wei,Tang Chun-Ping,Yao Sheng,et al. Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2021,19(11):868-873.
APA	Wu Jie-Wei,Tang Chun-Ping,Yao Sheng,Ke Chang-Qiang,&Ye Yang.(2021).Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L..CHINESE JOURNAL OF NATURAL MEDICINES,19(11),868-873.
MLA	Wu Jie-Wei,et al."Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.".CHINESE JOURNAL OF NATURAL MEDICINES 19.11(2021):868-873.