Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings

doi:10.1021/acs.orglett.1c03048

	Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings
	Wang, Zhen-Yu 2; Ma, Biao 1; Xu, Hui 1; Wang, Xing 1; Zhang, Xu 2; Dai, Hui-Xiong 1,2
刊名	ORGANIC LETTERS
	2021-11-05
卷号	23 期号:21 页码:8291-8295
ISSN号	1523-7060
DOI	10.1021/acs.orglett.1c03048
通讯作者	Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	Herein, we report the arylation, alkylation, and alkenylation of aryl ketones via a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. The use of the pyridine-oxazoline ligand is the key to the cleavage of the unstrained C-C bond. The late-stage arylation of aryl ketones derived from drugs and natural products demonstrated the synthetic utility of this protocol.
资助项目	Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, the Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; China Postdoctoral Science Foundation[2019M662854]
WOS关键词	CARBON-CARBON BONDS ; C-H BONDS ; DIRECTED CLEAVAGE ; CROSS-COUPLINGS ; ACTIVATION ; FUNCTIONALIZATION ; ETHERS ; CARBOACYLATION ; OLEFINS ; KETONES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000716793100035
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/299012]
专题	中国科学院上海药物研究所
通讯作者	Dai, Hui-Xiong
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhen-Yu,Ma, Biao,Xu, Hui,et al. Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings[J]. ORGANIC LETTERS,2021,23(21):8291-8295.
APA	Wang, Zhen-Yu,Ma, Biao,Xu, Hui,Wang, Xing,Zhang, Xu,&Dai, Hui-Xiong.(2021).Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings.ORGANIC LETTERS,23(21),8291-8295.
MLA	Wang, Zhen-Yu,et al."Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings".ORGANIC LETTERS 23.21(2021):8291-8295.