Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics

doi:10.1039/d1cc05157a

	Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics
	Tong, Pei-Hong 1,2; Zhu, Ling 1,2; Zang, Yi 3; Li, Jia 3; He, Xiao-Peng 1,2; James, Tony D.4,5
刊名	CHEMICAL COMMUNICATIONS
	2021-11-16
卷号	57 期号:91 页码:12098-12110
ISSN号	1359-7345
DOI	10.1039/d1cc05157a
通讯作者	Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk)
英文摘要	Biomacromolecular drugs have become an important class of therapeutic agents for the treatment of human diseases. Considering their high propensity for being degraded in the human body, the choice of an appropriate delivery system is key to ensure the therapeutic efficacy of biomacromolecular drugs in vivo. As an emerging class of supramolecular "host" materials, metal-organic frameworks (MOFs) exhibit advantages in terms of the tunabdity of pore size, encapsulation efficiency, controllable drug release, simplicity in surface functionalization and good biocompatibility. As a result, MOF-based host-guest systems have been extensively developed as a new class of flexible and powerful platform for the delivery of therapeutic biomacromolecules. In this review, we summarize current research progress in the synthesis of MOFs as delivery materials for a variety of biomacromolecules. Firstly, we briefly introduce the advances made in the use of biomacromolecular drugs for disease therapy and the types of commonly used clinical delivery systems. We then describe the advantages of using MOFs as delivery materials. Secondly, the strategies for the construction of MOF-encapsulated biomacromolecules (Biomacromolecules@MOFs) and the release mechanisms of the therapeutics are categorized. Thirdly, the application of MOFs to deliver different types of biomacromolecules (e.g., antigens/antibodies, enzymes, therapeutic proteins, DNA/RNA, polypeptides, and polysaccharides) for the treatment of various human diseases based on immunotherapy, gene therapy, starvation therapy and oxidation therapy is summarized. Finally, the remaining challenges and available opportunities for MOFs as drug delivery systems are outlined, which we anticipate will encourage additional research efforts directed towards developing Biomacromolecules@MOFs systems for biomedical applications.
资助项目	National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01]
WOS关键词	POOLED SIRNAS ; CO-DELIVERY ; CANCER ; THERAPY ; NANOPARTICLES ; STRATEGY ; VECTORS ; TUMOR ; RESISTANCE ; CHALLENGES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000712543700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298784]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; He, Xiao-Peng; James, Tony D.
作者单位	1.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 5.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Tong, Pei-Hong,Zhu, Ling,Zang, Yi,et al. Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics[J]. CHEMICAL COMMUNICATIONS,2021,57(91):12098-12110.
APA	Tong, Pei-Hong,Zhu, Ling,Zang, Yi,Li, Jia,He, Xiao-Peng,&James, Tony D..(2021).Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics.CHEMICAL COMMUNICATIONS,57(91),12098-12110.
MLA	Tong, Pei-Hong,et al."Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics".CHEMICAL COMMUNICATIONS 57.91(2021):12098-12110.