Application Potential of Mg-Zn-Nd Alloy as a Gastrointestinal Anastomosis Nail Material

doi:10.1007/s40195-021-01296-0

CORC > 金属研究所 > 中国科学院金属研究所

	Application Potential of Mg-Zn-Nd Alloy as a Gastrointestinal Anastomosis Nail Material
	Song, Lihui 1; Gao, Ming 2,3; Tan, Lili 3; Ma, Zheng 3; Ni, Peng 1; Zhou, Min 1; Na, Di 1
刊名	ACTA METALLURGICA SINICA-ENGLISH LETTERS
	2021-09-08
页码	12
关键词	Magnesium alloy Gastrointestinal tumor Absorbable Degradation rate
ISSN号	1006-7191
DOI	10.1007/s40195-021-01296-0
通讯作者	Na, Di(dawangmo@aliyun.com)
英文摘要	Gastrointestinal tumors are common malignant tumors in the digestive tract, of which gastric cancer is the third leading cause of cancer death and colorectal cancer is the fourth most deadly cancer. Nowadays, surgical resection remains to be one of the main measures for treating digestive tract tumors, and gastrointestinal anastomosis remains to be a key step in gastrointestinal surgery. Mg and its alloys have great potentials to be used for gastrointestinal anastomosis as anastomotic nail materials due to their biodegradability, good mechanical properties and biocompatibility. In this study, Mg-2Zn-0.5Nd (ZN20) alloy fine wires showed great potential as surgical staples. When we performed in vitro corrosion experiments, drainage fluid was collected from different parts of the patient's abdominal cavity after surgery for the first time to replace the traditional simulation fluid and to more realistically simulate the microenvironment required by the anastomotic nail. ZN20 alloy has an ultimate tensile strength of 256 MPa, an elongation rate of 12.56%, a tensile force in anastomosis of 16.8 N, and a rupture pressure after anastomosis at 17 kPa, which means that a sufficient mechanical support was provided after anastomosis. The statistical analysis and histopathological analysis of biochemical tests indicate that ZN20 alloy has no adverse effect on the normal metabolism of liver, kidney and body, but has superior biocompatibility and biosafety. This work confirms that ZN20 possesses a great application potential in the clinical field as a new type of gastrointestinal anastomotic nail material.
WOS研究方向	Metallurgy & Metallurgical Engineering
语种	英语
出版者	CHINESE ACAD SCIENCES, INST METAL RESEARCH
WOS记录号	WOS:000695736800001
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/166973]
专题	金属研究所_中国科学院金属研究所
通讯作者	Na, Di
作者单位	1.China Med Univ, Key Lab Precis Diag & Treatment Gastrointestinal, Dept Surg Oncol & Gen Surg, Minist Educ,Hosp 1, Shenyang 110001, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Song, Lihui,Gao, Ming,Tan, Lili,et al. Application Potential of Mg-Zn-Nd Alloy as a Gastrointestinal Anastomosis Nail Material[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2021:12.
APA	Song, Lihui.,Gao, Ming.,Tan, Lili.,Ma, Zheng.,Ni, Peng.,...&Na, Di.(2021).Application Potential of Mg-Zn-Nd Alloy as a Gastrointestinal Anastomosis Nail Material.ACTA METALLURGICA SINICA-ENGLISH LETTERS,12.
MLA	Song, Lihui,et al."Application Potential of Mg-Zn-Nd Alloy as a Gastrointestinal Anastomosis Nail Material".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2021):12.