Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction

doi:10.1016/j.matchemphys.2021.125219

CORC > 金属研究所 > 中国科学院金属研究所

	Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction
	Ullah, Ihsan 1,2; Xu, Qian 1,3; Jan, Haseen Ullah 4; Ren, Ling 1; Yang, Ke 1
刊名	MATERIALS CHEMISTRY AND PHYSICS
	2022
卷号	275 页码:13
关键词	Hydroxyapatite coating Plasma spraying Cytotoxicity Bioactivity Antibacterial
ISSN号	0254-0584
DOI	10.1016/j.matchemphys.2021.125219
通讯作者	Ren, Ling(lren@imr.ac.cn)
英文摘要	Recently the use of Sr2+ and Zn2+ ions substituted HA as an excellent biomaterial has been reported. To expand the usage to load-bearing applications, like hip replacement, it has been proposed that the material should be used in the form of a coating on the implant surface. In this work, we prepared Sr2+ and Zn2+ co-substituted HA plasma spray coating at different concentrations on titanium alloy (Ti-6Al-4V). All coatings showed excellent bonding strength with the substrate. The apatite layer formation on the coatings was studied via immersion in SBF. All samples exhibited great capability to induce the apatite layer formation on the coating surface, however, 10Zn5Sr-HA coating inhibited the apatite layer formation. The cell material interaction on the surfaces of the coatings was examined through MC3T3-E1 cell and demonstrated higher biocompatibility, protein adsorption ability, and significantly higher dissolution rate than pure HA coating. However, 10Zn5Sr-HA coating shows cytotoxicity which is confirmed by cell proliferation, cell adhesion, and ALP activity. Besides, some dead cells and poor cellular morphology were also found on the coating surface. The co-substituted HA coating revealed excellent antibacterial ability against bacterial colonization. The addition of Sr2+ to the Zn-HA coating effectively decreased the thermal instability, cytotoxicity, and increased performance as compared to HA coating. From the results, it is indicated that the 5Zn10Sr-HA coating has good bonding strength, bioactivity, biocompatibility, and antibacterial properties.
资助项目	Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069]
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000705723800002
资助机构	Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Liaoning Revitalization Talents Program
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/166581]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China 3.Northeastern Univ, Sch Mat & Engn, Dept Mat Phys & Chem, Key Lab Anisotropy & Texture Mat,Minist Educ, Shenyang 110819, Peoples R China 4.Univ Engn & Technol, Peshawar, Khyber Pakhtunk, Pakistan
推荐引用方式 GB/T 7714	Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,et al. Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,275:13.
APA	Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,Ren, Ling,&Yang, Ke.(2022).Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction.MATERIALS CHEMISTRY AND PHYSICS,275,13.
MLA	Ullah, Ihsan,et al."Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction".MATERIALS CHEMISTRY AND PHYSICS 275(2022):13.