Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism

doi:10.1093/molbev/msab241

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	Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism
	Li, Ao 2,3,8; Li, Li 3,4,5,8; Zhang, Ziyan 3,5,8; Li, Shiming 1,6; Wang, Wei 3,4,8; Guo, Ximing 7; Zhang, Guofan 2,3,8
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2021-11-01
卷号	38 期号:11 页码:5144-5155
关键词	thermal adaptation plasticity noncoding variation lipid synthesis ATP consumption oyster
ISSN号	0737-4038
DOI	10.1093/molbev/msab241
通讯作者	Li, Li(lili@qdio.ac.cn) ; Zhang, Guofan(gzhang@qdio.ac.cn)
英文摘要	Genetic variation and phenotypic plasticity are both important to adaptive evolution. However, how they act together on particular traits remains poorly understood. Here, we integrated phenotypic, genomic, and transcriptomic data from two allopatric but closely related congeneric oyster species, Crassostrea angulata from southern/warm environments and Crassostrea gigas from northern/cold environments, to investigate the roles of genetic divergence and plasticity in thermal adaptation. Reciprocal transplantation experiments showed that both species had higher fitness in their native habitats than in nonnative environments, indicating strong adaptive divergence. The southern species evolved higher transcriptional plasticity, and the plasticity was adaptive, suggesting that increased plasticity is important for thermal adaptation to warm climates. Genome-wide comparisons between the two species revealed that genes under selection tended to respond to environmental changes and showed higher sequence divergence in noncoding regions. All genes under selection and related to energy metabolism exhibited habitat-specific expression with genes involved in ATP production and lipid catabolism highly expressed in warm/southern habitats, and genes involved in ATP consumption and lipid synthesis were highly expressed in cold/northern habitats. The gene for acyl-CoA desaturase, a key enzyme for lipid synthesis, showed strong selective sweep in the upstream noncoding region and lower transcription in the southern species. These results were further supported by the lower free fatty acid (FFA) but higher ATP content in southern species and habitat, pointing to significance of ATP/FFA trade-off. Our findings provide evidence that noncoding variation and transcriptional plasticity play important roles in shaping energy metabolism for thermal adaptation in oysters.
资助项目	National Key R&D Program of China[2018YFD0900304] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA23050402] ; Distinguished Young Scientists Research Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences[KLEMB-DYS04] ; China Postdoctoral Science Foundation[2019TQ0324] ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q06] ; National Natural Science Foundation of China[31572620] ; Technology and Modern AgroIndustry Technology Research System[CARS-49]
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000715560700037
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/177200]
专题	海洋研究所_实验海洋生物学重点实验室海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Li, Li; Zhang, Guofan
作者单位	1.BGI Argo Seed Serv Wuhan Co Ltd, Wuhan, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Key Lab Ecol Mariculture, Qingdao, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China 7.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ USA 8.Chinese Acad Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Megasci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Li, Ao,Li, Li,Zhang, Ziyan,et al. Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(11):5144-5155.
APA	Li, Ao.,Li, Li.,Zhang, Ziyan.,Li, Shiming.,Wang, Wei.,...&Zhang, Guofan.(2021).Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism.MOLECULAR BIOLOGY AND EVOLUTION,38(11),5144-5155.
MLA	Li, Ao,et al."Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism".MOLECULAR BIOLOGY AND EVOLUTION 38.11(2021):5144-5155.