A deep-sea pathogenic Bacillus subtilis isolate employs different strategies to escape the killing of teleost and murine complements | |
Gu, Han-Jie2,3; Li, Mo-Fei3,4; Sun, Li1,3,4 | |
刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY |
2021-06-01 | |
卷号 | 119页码:8 |
关键词 | Bacillus subtilis Serum resistance Complement activation Immune evasion |
ISSN号 | 0145-305X |
DOI | 10.1016/j.dci.2021.104037 |
通讯作者 | Li, Mo-Fei(murphy210@163.com) ; Sun, Li(lsun@qdio.ac.cn) |
英文摘要 | Bacillus subtilis subsp. subtilis G7 was isolated from a deep-sea hydrothermal vent and is pathogenic to pathogenic to fish (Japanese flounder) and mice. G7 is able to survive in host sera and phagocytes. In this study, we investigated the underlying mechanism of G7 serum resistance. We found that (i) the remaining complement activity was very low in G7-incubated flounder serum but high in G7-incubated mouse serum; (ii) cleaved C3 and C5 components were detected on flounder serum-incubated G7 but not on mouse serum-incubated G7; (iii) abundant uncleaved C5 was localized in G7-incubated mouse, but not flounder, serum; (iv) G7-incubated flounder, but not mouse, serum exhibited strong chemotactic activity; (v) pre-treatment with low-dose lysozyme abolished the serum resistance of G7. Hence, G7 activates flounder complement but is protected from complement-mediated destruction by its cell wall structure, while G7 prevents the activation of mouse complement. These results indicate that G7 employs different mechanisms to avoid the complement killing of different hosts. |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050403] ; Qingdao National Laboratory for Marine Science and Technology[QNLM2016ORP0309] ; CAS Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences[KLMVI-OP202002] ; Taishan Scholar Program of Shandong Province |
WOS研究方向 | Fisheries ; Immunology ; Veterinary Sciences ; Zoology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000705082500005 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/176663] |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Li, Mo-Fei; Sun, Li |
作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.CATAS, Hainan Acad Trop Agr Resource, Inst Trop Biosci & Biotechnol, Haikou, Hainan, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Ctr Ocean Megasci, Inst Oceanol, Qingdao, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Gu, Han-Jie,Li, Mo-Fei,Sun, Li. A deep-sea pathogenic Bacillus subtilis isolate employs different strategies to escape the killing of teleost and murine complements[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,119:8. |
APA | Gu, Han-Jie,Li, Mo-Fei,&Sun, Li.(2021).A deep-sea pathogenic Bacillus subtilis isolate employs different strategies to escape the killing of teleost and murine complements.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,119,8. |
MLA | Gu, Han-Jie,et al."A deep-sea pathogenic Bacillus subtilis isolate employs different strategies to escape the killing of teleost and murine complements".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 119(2021):8. |
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