The MDM2/MDMX/p53 axis in the adaptive stress response

doi:10.21037/tcr.2019.12.89

	The MDM2/MDMX/p53 axis in the adaptive stress response
	Wang, Bing 1,2,3,4; Rasmussen-Ivey, Cody 4; Little, John B.4; Yuan, Zhi-Min 4
刊名	TRANSLATIONAL CANCER RESEARCH
	2020-03-01
卷号	9 期号:3 页码:1993-1997
关键词	The MDM2/MDMX/p53 axis mild stress adaptive stress response cell fate
ISSN号	2218-676X
DOI	10.21037/tcr.2019.12.89
通讯作者	Yuan, Zhi-Min(zyuan@hsph.harvard.edu)
英文摘要	Via regulation of cellular stress responses, p53 contributes to the maintenance of homeostasis. Contrary to its well-established pro-death function, p53 is also implicated in promoting cell survival by mediating the adaptive stress response. Emerging data reveal that the adaptive stress response is coupled with p53 decline that is a prerequisite for the induction of pro-survival pathways augmenting cell fitness. However, if the adaptive stress responses persist or become chronic, the sustained p53 downregulation would result in a permanent loss of p53 function and p53-dependent homeostasis. The available information suggests a model in which cells respond to different levels of stress by governing the activity and abundance of p53 that, in turn, determines the cell fate dependent on not only the intensity but also the duration of stress.
资助项目	Morningside Foundation ; National Cancer Institute at the National Institutes of Health[R01CA233558] ; National Cancer Institute at the National Institutes of Health[R01CA167814] ; National Cancer Institute at the National Institutes of Health[R01CA125144]
WOS关键词	EMBRYONIC LETHALITY ; P53 ACTIVITY ; MDM2-DEFICIENT MICE ; SUPPRESSES P53 ; MDM2 ; RESCUE ; STABILIZATION ; COMPLEX
WOS研究方向	Oncology
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000522761900070
资助机构	Morningside Foundation ; National Cancer Institute at the National Institutes of Health
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/140650]
专题	中国科学院近代物理研究所
通讯作者	Yuan, Zhi-Min
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 4.Harvard TH Chan Sch Publ Hlth, John B Little Ctr Radiat Sci, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Wang, Bing,Rasmussen-Ivey, Cody,Little, John B.,et al. The MDM2/MDMX/p53 axis in the adaptive stress response[J]. TRANSLATIONAL CANCER RESEARCH,2020,9(3):1993-1997.
APA	Wang, Bing,Rasmussen-Ivey, Cody,Little, John B.,&Yuan, Zhi-Min.(2020).The MDM2/MDMX/p53 axis in the adaptive stress response.TRANSLATIONAL CANCER RESEARCH,9(3),1993-1997.
MLA	Wang, Bing,et al."The MDM2/MDMX/p53 axis in the adaptive stress response".TRANSLATIONAL CANCER RESEARCH 9.3(2020):1993-1997.