Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)

doi:10.1080/15384101.2020.1838793

	Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)
	Zhang, Yi-Ming 2; Zhang, Li-Ying 2; Zhou, Heng 1,3; Li, Yang-Yang 2; Wei, Kong-Xi 2; Li, Cheng-Hao 2; Zhou, Ting 2; Wang, Ju-Fang 1,3; Wei, Wen-Jun 1,3; Hua, Jun-Rui 1,3
刊名	CELL CYCLE
	2020-10-31
页码	13
关键词	APS RIBE BMSCs Astragalus Polysaccharide Bystander Effect Apoptosis
ISSN号	1538-4101
DOI	10.1080/15384101.2020.1838793
通讯作者	Liu, Yong-Qi(liuyongqi73@163.com)
英文摘要	The purpose of this study was to investigate the effects of astragalus polysaccharides (APS) on the proliferation and apoptosis of bone marrow mesenchymal stem cells (BMSCs) induced by X-ray radiation-induced A549 cells bystander effect (RIBE), and to explore their mechanisms. In this study, APS increased the reduced cell proliferation rate induced by RIBE and inhibiting the apoptosis of bystander cells. In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. In addition, we believe that ROS may be the main cause of these protein changes. APS can inhibit the generation of ROS in bystander cells and thus inhibit the activation of the mitochondrial pathway, further preventing cellular damage caused by RIBE.
资助项目	National Natural Science Foundation of China[81973595] ; National Natural Science Foundation of China[82004094] ; Collaborative Innovation Project of Chinese and Tibetan Medicine[XBXT2015-1] ; Project of Gansu Provincial Education Department[2015A-095] ; Project of Lanzhou Municipal Science and Technology Bureau[2015-2-48]
WOS关键词	OXIDATIVE STRESS ; X-RAY ; IRRADIATION ; RESPONSES ; SURVIVAL ; THERAPY ; INJURY
WOS研究方向	Cell Biology
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000582898300001
资助机构	National Natural Science Foundation of China ; Collaborative Innovation Project of Chinese and Tibetan Medicine ; Project of Gansu Provincial Education Department ; Project of Lanzhou Municipal Science and Technology Bureau
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139521]
专题	中国科学院近代物理研究所
通讯作者	Liu, Yong-Qi
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China 2.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yi-Ming,Zhang, Li-Ying,Zhou, Heng,et al. Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)[J]. CELL CYCLE,2020:13.
APA	Zhang, Yi-Ming.,Zhang, Li-Ying.,Zhou, Heng.,Li, Yang-Yang.,Wei, Kong-Xi.,...&Liu, Yong-Qi.(2020).Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs).CELL CYCLE,13.
MLA	Zhang, Yi-Ming,et al."Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)".CELL CYCLE (2020):13.