Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer

doi:10.1021/acsami.0c16548

	Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer
	Du, Yanan 1,2,3; Sun, Hao 2,3; Lux, Francois 4,5; Xie, Yi 6; Du, Liqing 2,3; Xu, Chang 2,3; Zhang, Hong 6; He, Ningning 2,3; Wang, Jinhan 2,3; Liu, Yang 2,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-12-23
卷号	12 期号:51 页码:56874-56885
关键词	NSCLC cell lines AGuIX nanoparticles irradiation radiosensitization effect DNA damage repair
ISSN号	1944-8244
DOI	10.1021/acsami.0c16548
通讯作者	Wang, Yan(wangyan@irm-cams.ac.cn) ; Liu, Qiang(liuqiang@irm-cams.ac.cn)
英文摘要	Radiotherapy is the main treatment for cancer patients. A major concern in radiotherapy is the radiation resistance of some tumors, such as human nonsmall cell lung cancer. However, the radiation dose delivered to the tumors is often limited by the possibility of collateral damage to surrounding healthy tissues. A new and efficient gadolinium-based nanoparticle, AGuIX, has recently been developed for magnetic resonance imaging-guided radiotherapy and has been proven to act as an efficient radiosensitizer. The amplified radiation effects of AGuIX nanoparticles appear to be due to the emission of low-energy photoelectrons and Auger electron interactions. We demonstrated that AGuIX nanoparticles exacerbated radiation-induced DNA double-strand break damage and reduced DNA repair in the H1299 nonsmall cell lung cancer cell line. Furthermore, we observed a significant improvement in tumor cell damage and growth suppression, under radiation therapy, with the AGuIX nanoparticles in a H1299 mouse xenograft model. This study paves the way for research into the radiosensitization mechanism of AGuIX nanoparticles and provides a scientific basis for the use of AGuIX nanoparticles as radiosensitizing drugs.
资助项目	National Natural Science Foundation of China[31670859] ; National Natural Science Foundation of China[31971168] ; National Natural Science Foundation of China[31800703] ; Fundamental Research Funds for the Central Universities[3332018158] ; CAMS Innovation Fund for Medical Science[2017-I2M-1-016] ; China Postdoctoral Science Foundation[2018M630106] ; Natural Science Foundation of Tianjin[18JCYBJC26800] ; Natural Science Foundation of Tianjin[18JCQNJC12300] ; Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences[2017-1001-08]
WOS关键词	DNA-DAMAGE RESPONSE ; ATM PROTEIN-KINASE ; IONIZING-RADIATION ; OXIDATIVE STRESS ; RADIOTHERAPY ; ACTIVATION ; RADIORESISTANCE ; MECHANISMS ; CLEARANCE ; CARCINOMA
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000603397200019
资助机构	National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; CAMS Innovation Fund for Medical Science ; China Postdoctoral Science Foundation ; Natural Science Foundation of Tianjin ; Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/138196]
专题	中国科学院近代物理研究所
通讯作者	Wang, Yan; Liu, Qiang
作者单位	1.Tianjin Ctr Dis Control & Prevent, Tianjin 300011, Peoples R China 2.Chinese Acad Med Sci, Inst Radiat Med, Tianjin 300192, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Tianjin 300192, Peoples R China 4.Lyon Univ, Lyon1 Univ, Inst Light & Mater, UMR5306,CNRS, F-69100 Villeurbanne, France 5.NH TherAguix SAS, NH TherAguix, F-69100 Villeurbanne, France 6.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Du, Yanan,Sun, Hao,Lux, Francois,et al. Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(51):56874-56885.
APA	Du, Yanan.,Sun, Hao.,Lux, Francois.,Xie, Yi.,Du, Liqing.,...&Tillement, Olivier.(2020).Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer.ACS APPLIED MATERIALS & INTERFACES,12(51),56874-56885.
MLA	Du, Yanan,et al."Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer".ACS APPLIED MATERIALS & INTERFACES 12.51(2020):56874-56885.