Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling

doi:10.3390/ijms22020817

	Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
	Yan, Junfang 1,2,3,4,5; Xie, Yi 1,2,3,4; Si, Jing 1,2,3,4; Gan, Lu 1,2,3,4; Li, Hongyan 1,2,3,4; Sun, Chao 1,2,3,4; Di, Cuixia 1,2,3,4; Zhang, Jinhua 1,2,3,4,5; Huang, Guomin 1,2,3,4,5; Zhang, Xuetian 1,2,3,4,5
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2021
卷号	22 期号:2 页码:19
关键词	the caspase family mTOR signaling cell fate interplay
DOI	10.3390/ijms22020817
通讯作者	Xie, Yi(xieyi@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the two signaling pathways in regulating cell survival and determining cell fate under cellular stress. Members of the caspase family are crucial regulators of inflammation, endoplasmic reticulum stress response and apoptosis. mTOR signaling is known to mediate cell growth, nutrition and metabolism. For instance, over-nutrition can cause the hyperactivation of mTOR signaling, which is associated with diabetes. Nutrition deprivation can inhibit mTOR signaling via SH3 domain-binding protein 4. It is striking that Ras GTPase-activating protein 1 is found to mediate cell survival in a caspase-dependent manner against increasing cellular stress, which describes a new model of apoptosis. The components of mTOR signaling-raptor can be cleaved by caspases to control cell growth. In addition, mTOR is identified to coordinate the defense process of the immune system by suppressing the vitality of caspase-1 or regulating other interferon regulatory factors. The present review discusses the roles of the caspase family or mTOR pathway against cellular stress and generalizes their interplay mechanism in cell fate determination.
资助项目	National Key R&D Program of China[2018YFE0205100] ; Key Program of the National Natural Sciences Foundation of China[U1632270] ; Science and Technology Talent Project in Lanzhou[2018RC-66] ; Scientific Technology Research Projects of Gansu Province[20JR5RA551]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000611289800001
资助机构	National Key R&D Program of China ; Key Program of the National Natural Sciences Foundation of China ; Science and Technology Talent Project in Lanzhou ; Scientific Technology Research Projects of Gansu Province
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/138103]
专题	中国科学院近代物理研究所
通讯作者	Xie, Yi; Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China 2.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China
推荐引用方式 GB/T 7714	Yan, Junfang,Xie, Yi,Si, Jing,et al. Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(2):19.
APA	Yan, Junfang.,Xie, Yi.,Si, Jing.,Gan, Lu.,Li, Hongyan.,...&Zhang, Hong.(2021).Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(2),19.
MLA	Yan, Junfang,et al."Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.2(2021):19.