The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis

doi:10.3389/fonc.2021.620534

	The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis
	Li, Jie-yun 1,2,3; Li, Jing-wen 2,3; Jin, Yuan-chang 4,5,6; Li, Mei-xuan 1,2,3; Guo, Li-ping 1,2,3; Bing, Zhi-tong 5; Zhang, Qiu-ning 5,6; Bai, Fei 1,2,3,7; Wang, Xiao-hu 4,5,6; Li, Xiu-xia 1,2,3
刊名	FRONTIERS IN ONCOLOGY
	2021-05-25
卷号	11 页码:12
关键词	carbon ion radiotherapy proton therapy meningiomas systematic review meta-analysis
ISSN号	2234-943X
DOI	10.3389/fonc.2021.620534
通讯作者	Wang, Xiao-hu(xhwanggansu@163.com) ; Li, Xiu-xia(lixiuxia@lzu.edu.cn) ; Yang, Ke-hu(kehuyangebm2006@126.com)
英文摘要	Objective The purpose of this systematic review and meta-analysis is to evaluate the efficacy and safety of carbon ion radiotherapy (CI-RT) in improving meningioma by comparing photon and protons radiotherapy. Methods A comprehensive search for relevant studies published until March 17, 2021, was conducted in PubMed, the Cochrane Library, Chinese Biomedical Literature Database and EMBASE. Statistical analyses were performed with R 4.0.3. Results We identified 396 studies, of which 18 studies involving 985 participants were included. Except for one low quality study, the quality of the included studies was found to be either moderate or high quality. The analyses conducted according random effects model indicated that the 1-year overall survival rate (OS) of benign and non-benign meningiomas after the CI-RT treatment was 99% (95%CL=.91-1.00, I (2) = 0%). The overall average 5-year OS for meningiomas was 72% (95%CL=0.52-0.86, I (2) = 35%), not as effective as proton radiotherapy (PR-RT) 85% (95%CL=.72-.93, I (2) = 73, Q=4.17, df=2, p=.12). Additionally, 5-year OS of atypical meningiomas (81%) was found to be significantly higher than anaplastic meningiomas (52%). The 10-year OS after CI-RT of patients with mixed grade meningioma was 91% (95%CL=.75-.97, I (2) = 73%). The 15-year OS after CI-RT 87% (95%CL=.11-1.00) or PR-RT 87% (95%CL=.23-.99, I (2) = 79%) were the same (Q=0, df=1, p=.99). After undergoing CI-RT for 3 and 5 years, the LC for benign meningioma was 100% and 88%, respectively, while the 2-year LC of non-benign meningiomas (atypical/anaplastic) was 33%. Headache, sensory impairment, cognitive impairment, and hearing impairment were found to be the most common adverse reactions, with individual incidences of 19.4%, 23.7%, 9.1%, and 9.1%, respectively. Conclusion CI-RT is a rapidly developing technique that has been proven to be an effective treatment against meningioma. The efficacy and safety of CI-RT for meningiomas were similar to those of PR-RT, better than photon radiotherapy (PH-RT). However, there is a need for more prospective trials in the future that can help provide more supportive evidence.
资助项目	National Social Science Fund of China[19ZDA142] ; Key Laboratory of Evidence Based Medicine and Knowledge Translation Foundation of Gansu Province[GSEBMKT-2020KF01]
WOS关键词	ATYPICAL MENINGIOMAS ; MALIGNANT MENINGIOMAS ; PROTON THERAPY ; BENIGN ; IRRADIATION ; RECURRENCE ; MANAGEMENT ; SURGERY ; QUALITY ; RATES
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000658693700001
资助机构	National Social Science Fund of China ; Key Laboratory of Evidence Based Medicine and Knowledge Translation Foundation of Gansu Province
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137190]
专题	中国科学院近代物理研究所
通讯作者	Wang, Xiao-hu; Li, Xiu-xia; Yang, Ke-hu
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Publ Hlth, Hlth Technol Assessment Ctr, Lanzhou, Peoples R China 3.Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China 4.Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China 5.Chinese Acad Sci, Inst Modern Phys, Beijing, Peoples R China 6.Lanzhou Heavy Ions Hosp, Lanzhou, Peoples R China 7.Natl Hlth Commiss Med Management Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Jie-yun,Li, Jing-wen,Jin, Yuan-chang,et al. The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ONCOLOGY,2021,11:12.
APA	Li, Jie-yun.,Li, Jing-wen.,Jin, Yuan-chang.,Li, Mei-xuan.,Guo, Li-ping.,...&Yang, Ke-hu.(2021).The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis.FRONTIERS IN ONCOLOGY,11,12.
MLA	Li, Jie-yun,et al."The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis".FRONTIERS IN ONCOLOGY 11(2021):12.