Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury

doi:10.3389/fcimb.2021.577236

	Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
	Li, Yangyang 2; Zhang, Yiming 2; Wei, Kongxi 2; He, Jinpeng 3,4; Ding, Nan 3,4; Hua, Junrui 3,4; Zhou, Ting 2; Niu, Fan 2; Zhou, Gucheng 2; Shi, Tongfan 2
刊名	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
	2021-07-09
卷号	11 页码:13
关键词	radiotherapy gut microbiota dysbiosis metabolites SCFAs radiation-induced intestinal injury
ISSN号	2235-2988
DOI	10.3389/fcimb.2021.577236
通讯作者	Zhang, Liying(zhangliying201212@163.com) ; Liu, Yongqi(liuyongqi73@163.com)
英文摘要	Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbiota can always be affected by various factors and among them, it is radiotherapy that results in gut microbiota (12)dysbiosis and it is often embodied in a decrease in the abundance and diversity of gut microbiota, an increase in harmful bacteria and a decrease in beneficial bacteria, thereby affecting many disease states, especially intestine diseases. Furthermore, gut microbiota can produce a variety of metabolites, among which short-chain fatty acids (SCFAs) are one of the most abundant and important metabolites. More importantly, SCFAs can be identified as second messengers to promote signal transduction and affect the occurrence and development of diseases. Radiotherapy can lead to the alterations of SCFAs-producing bacteria and cause changes in SCFAs, which is associated with a variety of diseases such as radiation-induced intestinal injury. However, the specific mechanism of its occurrence is not yet clear. Therefore, this review intends to emphasize the alterations of gut microbiota after radiotherapy and highlight the alterations of SCFAs-producing bacteria and SCFAs to explore the mechanisms of radiation-induced intestinal injury from the perspective of gut microbiota and its metabolite SCFAs.
资助项目	National Natural Science Foundation of China[81973595] ; National Natural Science Foundation of China[82004094] ; China Postdoctoral Science Foundation Project[2021M693794] ; Open Fund Project of Key Laboratory of Dunhuang Medicine and Translational Education Ministry[DHYX19-13]
WOS关键词	CHAIN FATTY-ACIDS ; INFLAMMATORY-BOWEL-DISEASE ; HISTONE DEACETYLASE ; SODIUM-BUTYRATE ; VALPROIC ACID ; DOUBLE-BLIND ; CANCER ; HEALTH ; PREVENTION ; PROBIOTICS
WOS研究方向	Immunology ; Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000677391500001
资助机构	National Natural Science Foundation of China ; China Postdoctoral Science Foundation Project ; Open Fund Project of Key Laboratory of Dunhuang Medicine and Translational Education Ministry
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136768]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Liying; Liu, Yongqi
作者单位	1.Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China 2.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 5.Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Yangyang,Zhang, Yiming,Wei, Kongxi,et al. Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2021,11:13.
APA	Li, Yangyang.,Zhang, Yiming.,Wei, Kongxi.,He, Jinpeng.,Ding, Nan.,...&Liu, Yongqi.(2021).Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,11,13.
MLA	Li, Yangyang,et al."Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 11(2021):13.