Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides

doi:10.1021/acs.jafc.0c01958

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	Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides
	Qian, Dandan ; Qiu, Bin 2,3; Zhou, Nan ; Takaiwa, Fumio 1; Yong, Weidong 2,3; Qu, Le Qing
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2020
卷号	68 期号:27 页码:7162-7168
关键词	antihypertensive peptide transgenic rice hypertension food-derived bioactive peptide spontaneously hypertensive rats systolic blood pressure
ISSN号	0021-8561
DOI	10.1021/acs.jafc.0c01958
文献子类	Article
英文摘要	Peptides derived from food protein have the potential to become antihypertensive agents with relatively few negative side effects. Herein, multiple antihypertensive peptides, extracted from the transgenic rice seed, were administered intragastrically into spontaneously hypertensive rats (SHRs) with different dosages, resulting in a significant decrease in the systolic blood pressure (SBP). Furthermore, for a period of 5 weeks, daily intragastric administration of the transgenic rice flour also significantly reduced the SBP of SHRs but not the Wistar Kyoto normotensive rats (WNRs), most importantly, which did not affect the growth, development, or serum chemistry of SHRs or WNRs and did not cause any pathological changes. Our work provides an alternative source of natural antihypertensive agents.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
电子版国际标准刊号	1520-5118
出版地	WASHINGTON
WOS关键词	I-CONVERTING-ENZYME ; INHIBITORY PEPTIDES ; BLOOD-PRESSURE ; EXPRESSION ; PROTEIN ; DESIGN
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000550642300010
资助机构	National Program of Transgenic Variety Development of China [2016ZX08001-006]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/21669]
专题	中科院植物分子生理学重点实验室
作者单位	1.Peking Union Med Coll, Beijing 100021, Peoples R China 2.Chinese Acad Sci, Innovat Acad Seed Design, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 3.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China 4.Natl Agr & Food Res Org, Div Biotechnol, Plant Mol Farming Unit, Inst Agrobiol Sci, Tsukuba, Ibaraki 3058602, Japan
推荐引用方式 GB/T 7714	Qian, Dandan,Qiu, Bin,Zhou, Nan,et al. Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(27):7162-7168.
APA	Qian, Dandan,Qiu, Bin,Zhou, Nan,Takaiwa, Fumio,Yong, Weidong,&Qu, Le Qing.(2020).Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(27),7162-7168.
MLA	Qian, Dandan,et al."Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.27(2020):7162-7168.