Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response

doi:10.1111/nph.15874

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	Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response
	Huang, Shuangzhan ; Zhang, Ai ; Jin, Jing Bo 4; Zhao, Bo 1,2; Wang, Tian-Jing ; Wu, Yifan ; Wang, Shuang ; Liu, Yutong ; Wang, Jie ; Guo, Peng
刊名	NEW PHYTOLOGIST
	2019
卷号	223 期号:3 页码:1372-1387
关键词	abiotic stress abscisic acid (ABA) Arabidopsis thaliana dehydration stress histone demethylation transcriptional regulation
ISSN号	0028-646X
DOI	10.1111/nph.15874
文献子类	Article
英文摘要	Under dehydration in plants, antagonistic activities of histone 3 lysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic state of gene expression by orientating transcriptional reprogramming toward growth or stress tolerance. However, the histone demethylase that specifically controls histone methylation homeostasis under dehydration stress remains unknown. Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1 family, plays crucial roles in response to dehydration stress and abscisic acid (ABA) in Arabidopsis thaliana. jmj17 loss-of-function mutants displayed dehydration stress tolerance and ABA hypersensitivity in terms of stomatal closure. JMJ17 specifically demethylated H3K4me1/2/3 via conserved iron-binding amino acids in vitro and in vivo. Moreover, H3K4 demethylase activity of JMJ17 was required for dehydration stress response. Systematic combination of genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) analyses revealed that a loss-of-function mutation in JMJ17 caused an ectopic increase in genome-wide H3K4me3 levels and activated a plethora of dehydration stress-responsive genes. Importantly, JMJ17 bound directly to the chromatin of OPEN STOMATA 1 (OST1) and demethylated H3K4me3 for the regulation of OST1 mRNA abundance, thereby modulating the dehydration stress response. Our results demonstrate a new function of a histone demethylase under dehydration stress in plants.
学科主题	Plant Sciences
电子版国际标准刊号	1469-8137
出版地	HOBOKEN
WOS关键词	ABSCISIC-ACID RESPONSES ; TRANS-GOLGI NETWORK ; TRANSCRIPTION FACTORS ; CENTRAL VACUOLE ; PROTEIN-KINASE ; GUARD-CELLS ; CHROMATIN ; TRITHORAX ; MEMBRANE ; MUTANTS
WOS研究方向	Plant Sciences
语种	英语
出版者	WILEY
WOS记录号	WOS:000475918000029
资助机构	Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [#2412018BJ002] Funding Source: Medline ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31601311, 31771352] Funding Source: Medline ; Natural Science Foundation of Jilin Province of China [20180101233JC] Funding Source: Medline ; National Key Research and Development Program of China [2016YFD0102003] Funding Source: Medline
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/19753]
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Mol Physiol, Beijing 100093, Peoples R China 2.Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA 3.Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA 4.Northeast Normal Univ, Minist Educ MOE, Key Lab Mol Epigenet, Changchun 130024, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Huang, Shuangzhan,Zhang, Ai,Jin, Jing Bo,et al. Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response[J]. NEW PHYTOLOGIST,2019,223(3):1372-1387.
APA	Huang, Shuangzhan.,Zhang, Ai.,Jin, Jing Bo.,Zhao, Bo.,Wang, Tian-Jing.,...&Xu, Zheng-Yi.(2019).Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response.NEW PHYTOLOGIST,223(3),1372-1387.
MLA	Huang, Shuangzhan,et al."Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response".NEW PHYTOLOGIST 223.3(2019):1372-1387.