Transposable elements drive rapid phenotypic variation in Capsella rubella

doi:10.1073/pnas.1811498116

CORC > 植物研究所 > 中国科学院植物研究所 > 系统与进化植物学国家重点实验室

	Transposable elements drive rapid phenotypic variation in Capsella rubella
	Niu, Xiao-Min ; Xu, Yong-Chao ; Li, Zi-Wen ; Bian, Yu-Tao ; Hou, Xing-Hui ; Chen, Jia-Fu ; Zou, Yu-Pan ; Jiang, Juan ; Wu, Qiong ; Ge, Song
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2019
卷号	116 期号:14 页码:6908-6913
关键词	Brassicaceae Capsella rubella natural variation rapid phenotypic variation transposable elements
ISSN号	0027-8424
DOI	10.1073/pnas.1811498116
文献子类	Article
英文摘要	Rapid phenotypic changes in traits of adaptive significance are crucial for organisms to thrive in changing environments. How such phenotypic variation is achieved rapidly, despite limited genetic variation in species that experience a genetic bottleneck is unknown. Capsella rubella, an annual and inbreeding forb (Brassicaceae), is a great system for studying this basic question. Its distribution is wider than those of its congeneric species, despite an extreme genetic bottleneck event that severely diminished its genetic variation. Here, we demonstrate that transposable elements (TEs) are an important source of genetic variation that could account for its high phenotypic diversity. TEs are (i) highly enriched in C. rubella compared with its outcrossing sister species Capsella grandiflora, and (ii) 4.2% of polymorphic TEs in C. rubella are associated with variation in the expression levels of their adjacent genes. Furthermore, we show that frequent TE insertions at FLOWERING LOCUS C (FLC) in natural populations of C. rubella could explain 12.5% of the natural variation in flowering time, a key life history trait correlated with fitness and adaptation. In particular, we show that a recent TE insertion at the 3' UTR of FLC affects mRNA stability, which results in reducing its steady-state expression levels, to promote the onset of flowering. Our results highlight that TE insertions can drive rapid phenotypic variation, which could potentially help with adaptation to changing environments in a species with limited standing genetic variation.
学科主题	Multidisciplinary Sciences
出版地	WASHINGTON
WOS关键词	ARABIDOPSIS-THALIANA ; GENETIC PARADOX ; RECENT SPECIATION ; FLOWERING-TIME ; ADAPTATION ; EVOLUTION ; MUTATION ; IDENTIFICATION ; CONSEQUENCES ; EXPRESSION
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000463069900067
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91731306] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27010305] ; Innovative Academy of Seed Design, Chinese Academy of Sciences ; Chinese Academy of Sciences President's International Fellowship for Visiting Scientists ; Monash University Larkins Fellowship
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/19750]
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Niu, Xiao-Min,Xu, Yong-Chao,Li, Zi-Wen,et al. Transposable elements drive rapid phenotypic variation in Capsella rubella[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(14):6908-6913.
APA	Niu, Xiao-Min.,Xu, Yong-Chao.,Li, Zi-Wen.,Bian, Yu-Tao.,Hou, Xing-Hui.,...&Guo, Ya-Long.(2019).Transposable elements drive rapid phenotypic variation in Capsella rubella.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(14),6908-6913.
MLA	Niu, Xiao-Min,et al."Transposable elements drive rapid phenotypic variation in Capsella rubella".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.14(2019):6908-6913.