Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China

doi:10.3389/fnut.2021.790520

	Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China
	Geng, Hao 1,2,3; Wang, Shijing 3; Jin, Yan 3; Cheng, Nan 3; Song, Bin 3; Shu, Shan 3; Li, Bo 3; Han, Yongsheng 3; Han, Yongzhu 3; Gao, Lishen 1,2
刊名	FRONTIERS IN NUTRITION
	2021-12-31
卷号	8
关键词	Wilson's disease nutritional status body composition NRS2002 phenotype
ISSN号	2296-861X
DOI	10.3389/fnut.2021.790520
通讯作者	Wang, Xun(neurodocwx@163.com) ; Ma, Zuchang(zcmaiim@163.com) ; Sun, Yining(iimsunyn@sina.com)
英文摘要	Background: Abnormal nutritional status is frequently seen in patients with chronic diseases. To date, no study has investigated the detailed characteristics of abnormal nutritional status among Wilson's disease (WD) patients in the Chinese cohort. This study aimed to describe the nutritional status of WD patients, with a particular focus on the differences between patients with different phenotypes.Methods: The study subjects comprised 119 healthy controls, 129 inpatients (hepatic subtype, n = 34; neurological subtype, n = 95) who were being treated at the affiliated hospital of the Institute of Neurology, Anhui University of Chinese Medicine. All of the subjects were assessed for body composition by using bioelectrical impedance analysis. All WD patients received anthropometry, nutritional risk screening 2002 (NRS2002), and laboratory test (hemocyte and serum biomarkers) additionally.Results: Compared with healthy controls, the fat mass and rate of total body and trunk were significantly higher in WD patients (P < 0.001), the muscle and skeletal muscle mass of total body and trunk were significantly lower in WD patients (P < 0.001). Compared with hepatic subtype patients, the fat mass and rate of total body, trunk, and limbs were significantly lower in neurological subtype patients (P<0.01); while there were no significant differences in muscle and skeletal muscle between these two subtypes. The overall prevalence of abnormal nutritional status in WD patients was 43.41% (56/129). The prevalence of high-nutritional risk and overweight in WD patients was 17.83% (23 of 129) and 25.58% (33 of 129), respectively. Compare with patients with high nutritional risk, macro platelet ratio, alkaline phosphatase, the basal metabolic rate (p < 0.05), creatinine, trunk fat rate (p < 0.01) and appendicular skeletal muscle mass (p < 0.001) were significantly higher in patients without nutritional risk (p < 0.001). Patients with a high nutritional risk tend to have a lower cholinesterase concentration (x(2) = 4.227, p < 0.05).Conclusion: Both patients with H-subtype and N-subtype are prone to have an abnormal nutritional status. Longitudinal studies are required to investigate if nutritional status and body composition could reflect prognosis in WD patients, and which of these body composition indexes contribute to malnutrition and worse prognosis.
WOS关键词	TO-HIP RATIO ; MASS INDEX ; WAIST ; SEVERITY
WOS研究方向	Nutrition & Dietetics
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000745121800001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/127341]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Xun; Ma, Zuchang; Sun, Yining
作者单位	1.Univ Sci & Technol China, Dept Biophys, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machine, Lab Sports & Nutr Informat Technol, Hefei, Peoples R China 3.Anhui Univ Chinese Med, Inst Neurol, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Geng, Hao,Wang, Shijing,Jin, Yan,et al. Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China[J]. FRONTIERS IN NUTRITION,2021,8.
APA	Geng, Hao.,Wang, Shijing.,Jin, Yan.,Cheng, Nan.,Song, Bin.,...&Sun, Yining.(2021).Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China.FRONTIERS IN NUTRITION,8.
MLA	Geng, Hao,et al."Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China".FRONTIERS IN NUTRITION 8(2021).