Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review

doi:10.1007/s00432-021-03895-x

	Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review
	Chen, Yamei 2; Jin, Ying 2,3; Hu, Xiao 2,4; Chen, Ming 1,2
刊名	JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
	2022-01-08
关键词	Small cell lung cancer Tumor-infiltrating lymphocyte T cell Tumor microenvironment
ISSN号	0171-5216
DOI	10.1007/s00432-021-03895-x
通讯作者	Hu, Xiao(huxiao@zjcc.org.cn) ; Chen, Ming(chenming@zicc.org.cn)
英文摘要	Immune checkpoint inhibitors (ICIs) have brought new hope for the treatment of patients with small cell lung cancer (SCLC) over the past decades. However, the overall response rate is limited, and is lower than that in non-small cell lung cancer (NSCLC). This is in part because of the lack of pre-existing tumor-infiltrating T lymphocytes (TITLs), especially cytotoxic T cells (CTLs), in the SCLC tumor microenvironment (TME), resulting in insufficient anti-tumor immune response. To unleash the full potential of ICIs, the trafficking and infiltration of TITLs to the tumor is necessary and tightly regulated, the highly immunosuppressive tumor microenvironment blunts the infiltration and function of TITLs that reach the tumor in SCLC. Here, we review the characteristics of TITLs, the effects of various factors on T cell infiltration, and possible strategies to restore or promote T cell infiltration in the TME of SCLC.
资助项目	National Natural Science Foundation of China[81672972] ; Medical and Health Science Foundation of Zhe Jiang Province[2018255396] ; Medical and Health Science Foundation of Zhe Jiang Province[2019PY002]
WOS关键词	ENDOTHELIAL GROWTH-FACTOR ; DNA-DAMAGE RESPONSE ; PD-L1 EXPRESSION ; ANTITUMOR IMMUNITY ; EXTRACELLULAR-MATRIX ; MESSENGER-RNA ; PROGNOSIS ; IMMUNOTHERAPY ; INHIBITION ; RECEPTORS
WOS研究方向	Oncology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000740400500002
资助机构	National Natural Science Foundation of China ; Medical and Health Science Foundation of Zhe Jiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/127239]
专题	中国科学院合肥物质科学研究院
通讯作者	Hu, Xiao; Chen, Ming
作者单位	1.Sun Yat Sen Univ, Dept Radiat Oncol, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Key Lab Radiat Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Dept Med Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Dept Radiat Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yamei,Jin, Ying,Hu, Xiao,et al. Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2022.
APA	Chen, Yamei,Jin, Ying,Hu, Xiao,&Chen, Ming.(2022).Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY.
MLA	Chen, Yamei,et al."Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022).