Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy

doi:10.1039/d1nr06353g

	Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy
	Jiang, Kai 1; Zhao, Di 2; Ye, Rui 1; Liu, Xinlong 5; Gao, Chao 1; Guo, Yuanyuan 5; Zhang, Chuan 5; Zeng, Jian 3,4; Wang, Shi 3,4; Song, Jie 1,3,4
刊名	NANOSCALE
	2021-12-20
ISSN号	2040-3364
DOI	10.1039/d1nr06353g
通讯作者	Song, Jie(sjie@sjtu.edu.cn)
英文摘要	Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorder treatment. However, most of the traditional SNA core materials are non-degradable materials, so it is worthy of further research. Herein, we report a spherical nucleic acid based on poly-hyaluronic acid (PHA) for the co-delivery of a typical chemotherapeutic drug, doxorubicin (DOX), and an antisense oligonucleotide (ASO) against the tissue inhibitor of metalloproteinases 1 (TIMP-1) for the treatment of hypertrophic scars (HS) which are caused by abnormal fibroblast proliferation. Our study showed that PHA-based SNAs simultaneously bearing TIMP-1 ASO and DOX (termed PHAAD) could significantly promote skin penetration, improve the cellular uptake, and effectively down-regulate the TIMP-1 expression and enhance the cytotoxicity of DOX. Moreover, PHAAD nanoparticles facilitated the apoptosis of hypertrophic scar cells, and reduced the burden and progression of hypertrophic scars in a xenografted mouse model without adverse side effects. Thus, our PHA-based SNA represents a new transdermal delivery vehicle for efficient combinatorial chemo and gene therapy, which is expected to treat various skin disorders.
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[22161132008] ; National Natural Science Foundation of China[22108172] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; Project of Shanghai Jiao Tong University[2019QYA03] ; Project of Shanghai Jiao Tong University[YG2017ZD07] ; Institute of Basic Medicine and Cancer (IBMC) ; Chinese Academy of Sciences
WOS关键词	ANTISENSE OLIGONUCLEOTIDES ; HYPERTROPHIC SCARS ; DRUG-DELIVERY ; SIRNA ; NANOPARTICLES ; CHALLENGES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000743605400001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; Project of Shanghai Jiao Tong University ; Institute of Basic Medicine and Cancer (IBMC) ; Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/127123]
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Jie
作者单位	1.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Inst Nano Biomed & Engn, Dept Instrument Sci & Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 2.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 5.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Kai,Zhao, Di,Ye, Rui,et al. Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy[J]. NANOSCALE,2021.
APA	Jiang, Kai.,Zhao, Di.,Ye, Rui.,Liu, Xinlong.,Gao, Chao.,...&Song, Jie.(2021).Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy.NANOSCALE.
MLA	Jiang, Kai,et al."Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy".NANOSCALE (2021).