Modulation of MagR magnetic properties via iron-sulfur cluster binding

doi:10.1038/s41598-021-03344-2

	Modulation of MagR magnetic properties via iron-sulfur cluster binding
	Guo, Zhen 1; Xu, Shuai 5; Chen, Xue 2; Wang, Changhao 5; Yang, Peilin 1; Qin, Siying 1; Zhao, Cuiping 4; Fei, Fan 5; Zhao, Xianglong 5; Tan, Ping-Heng 2
刊名	SCIENTIFIC REPORTS
	2021-12-14
卷号	11
ISSN号	2045-2322
DOI	10.1038/s41598-021-03344-2
通讯作者	Xie, Can(canxie@hmfl.ac.cn)
英文摘要	Iron-sulfur clusters are essential cofactors found in all kingdoms of life and play essential roles in fundamental processes, including but not limited to respiration, photosynthesis, and nitrogen fixation. The chemistry of iron-sulfur clusters makes them ideal for sensing various redox environmental signals, while the physics of iron-sulfur clusters and its host proteins have been long overlooked. One such protein, MagR, has been proposed as a putative animal magnetoreceptor. It forms a rod-like complex with cryptochromes (Cry) and possesses intrinsic magnetic moment. However, the magnetism modulation of MagR remains unknown. Here in this study, iron-sulfur cluster binding in MagR has been characterized. Three conserved cysteines of MagR play different roles in iron-sulfur cluster binding. Two forms of iron-sulfur clusters binding have been identified in pigeon MagR and showed different magnetic properties: [3Fe-4S]-MagR appears to be superparamagnetic and has saturation magnetization at 5 K but [2Fe-2S]-MagR is paramagnetic. While at 300 K, [2Fe-2S]-MagR is diamagnetic but [3Fe-4S]-MagR is paramagnetic. Together, the different types of iron-sulfur cluster binding in MagR attribute distinguished magnetic properties, which may provide a fascinating mechanism for animals to modulate the sensitivity in magnetic sensing.
资助项目	Presidential Foundation of Hefei Institutes of Physical Science (HFIPS) ; Chinese Academy of Sciences[BJZX201901] ; HFIPS Director's Fund[YZJJZX202014] ; National Key Research and Development Program of China[2021YFA1600100] ; National Natural Science Foundation of China[31640001]
WOS关键词	FE-S PROTEINS ; 4FE-4S CLUSTER ; BIOGENESIS ; 2FE-2S ; CRYPTOCHROME ; MECHANISM ; ISCA ; MAGNETORECEPTION ; EUKARYOTES ; REQUIRES
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000730779300047
资助机构	Presidential Foundation of Hefei Institutes of Physical Science (HFIPS) ; Chinese Academy of Sciences ; HFIPS Director's Fund ; National Key Research and Development Program of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126956]
专题	中国科学院合肥物质科学研究院
通讯作者	Xie, Can
作者单位	1.Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Lab Mol Biophys, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Semicond, State Key Lab Superlattices & Microstruct, Beijing 100083, Peoples R China 3.Int Magnetobiol Frontier Res Ctr, Hefei 230031, Peoples R China 4.Rutgers State Univ, Dept Microbiol & Biochem, New Brunswick, NJ USA 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Guo, Zhen,Xu, Shuai,Chen, Xue,et al. Modulation of MagR magnetic properties via iron-sulfur cluster binding[J]. SCIENTIFIC REPORTS,2021,11.
APA	Guo, Zhen.,Xu, Shuai.,Chen, Xue.,Wang, Changhao.,Yang, Peilin.,...&Xie, Can.(2021).Modulation of MagR magnetic properties via iron-sulfur cluster binding.SCIENTIFIC REPORTS,11.
MLA	Guo, Zhen,et al."Modulation of MagR magnetic properties via iron-sulfur cluster binding".SCIENTIFIC REPORTS 11(2021).