Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy

doi:10.1002/jmri.28018

	Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy
	Liu, Jin 1,2,3; Wang, Wenjuan 2,4,5; Zhou, Yanfei 1,3; Gan, Chen 3; Wang, Tengfei 1,3; Hu, Zongtao 1,3; Lou, Jianjun 1,3; Wang, Hongzhi 1,3; Yang, Li-Zhuang 1,3; Wong, Stephen T. C.6,7
刊名	JOURNAL OF MAGNETIC RESONANCE IMAGING
	2021-12-02
关键词	nasopharyngeal carcinoma along-tract analysis diffusion tensor imaging radiotherapy radiation-induced brain injury imaging biomarkers
ISSN号	1053-1807
DOI	10.1002/jmri.28018
通讯作者	Yang, Li-Zhuang(lzyang@ustc.edu.cn) ; Li, Hai(hli@cmpt.ac.cn)
英文摘要	Background Patients receiving cranial radiation face the risk of delayed brain dysfunction. However, an early medical imaging marker is not available until irreversible morphological changes emerge. Purpose To explore the micromorphological white matter changes during the radiotherapy session by utilizing an along-tract analysis framework. Study Type Prospective. Population Eighteen nasopharyngeal carcinoma (two female) patients receiving cranial radiation. Field Strength/Sequence 3.0 T; Diffusion tensor imaging (DTI) and T1- and T2-weighted images (T1W, T2W); computed tomography (CT). Assessment Patients received three DTI imaging scans during the radiotherapy (RT), namely the baseline scan (1-2 days before RT began), the middle scan (the middle of the RT session), and the end scan (1-2 days after RT ended). Twelve fibers were segmented after whole-brain tractography. Then, the fractional anisotropy (FA) values and the cumulative radiation dose received for each fiber streamline were resampled and projected into their center fiber. Statistical Tests The contrast among the three scans (P1: middle scan-baseline scan; P2: end scan-middle scan; P3: end scan-baseline scan) were compared using the linear mixed model for each of the 12 center fibers. Then, a dose-responsiveness relationship was performed using Pearson correlation. P < 0.05 was considered statistically significant. Results Six of the 12 center fibers showed significant changes of FA values during the RT but with heterogeneous patterns. The significant changes along a specific center fiber were associated with their cumulative dose received (Genu: P1 r = -0.6182, P2 r = -0.5907; Splenium: P1 r = 0.4055, P = 0.1063, P2 r = 0.6742; right uncinate fasciculus: P1 r = -0.3865, P2 r = -0.4912, P = 0.0533; right corticospinal tract: P1 r = 0.4273, P = 0.1122, P2 r = -0.6885). Data Conclusion The along-tract analysis might provide sensitive measures on the early-onset micromorphological changes. Level of Evidence 2 Technical Efficacy Stage 3
资助项目	Key R&D Program of Anhui Province[201904a07020104] ; Natural Science Fund of Anhui Province[2008085MC69] ; General scientific research project of Anhui Provincial Health Commission[AHWJ2021b150] ; Natural Science Fund of Hefei City[2021033] ; Collaborative Innovation Program of Hefei Science Center, CAS[2020HSC-CIP001] ; Collaborative Innovation Program of Hefei Science Center, CAS[2021HSC-CIP013] ; Anhui Province Key Laboratory of Medical Physics and Technology[LMPT201904] ; John S Dunn Research Foundation ; WF Chao Foundation
WOS关键词	INDUCED BRAIN-INJURY ; DIFFUSION TENSOR ; NASOPHARYNGEAL CARCINOMA ; WHITE-MATTER ; TRACTOGRAPHY ; IRRADIATION ; STATISTICS ; DAMAGE
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	WILEY
WOS记录号	WOS:000724835200001
资助机构	Key R&D Program of Anhui Province ; Natural Science Fund of Anhui Province ; General scientific research project of Anhui Provincial Health Commission ; Natural Science Fund of Hefei City ; Collaborative Innovation Program of Hefei Science Center, CAS ; Anhui Province Key Laboratory of Medical Physics and Technology ; John S Dunn Research Foundation ; WF Chao Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126816]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Li-Zhuang; Li, Hai
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol, Hefei, Peoples R China 2.Univ Sci & Technol China, Hefei, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Peoples R China 4.Univ Sci & Technol China, Ctr Biomed Engn, Dept Elect Sci & Technol, Hefei, Peoples R China 5.Anhui Agr Univ, Sch Sci, Hefei, Peoples R China 6.Houston Methodist Canc Ctr, Dept Syst Med & Bioengn, Houston, TX USA 7.Cornell Univ, Weill Cornell Med Coll, Dept Radiol & Neurosci, Houston, TX USA
推荐引用方式 GB/T 7714	Liu, Jin,Wang, Wenjuan,Zhou, Yanfei,et al. Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2021.
APA	Liu, Jin.,Wang, Wenjuan.,Zhou, Yanfei.,Gan, Chen.,Wang, Tengfei.,...&Li, Hai.(2021).Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy.JOURNAL OF MAGNETIC RESONANCE IMAGING.
MLA	Liu, Jin,et al."Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy".JOURNAL OF MAGNETIC RESONANCE IMAGING (2021).