Advanced glycation end products via skin autofluorescence as potential marker of carotid atherosclerosis in patients with type 2 diabetes

doi:10.1016/j.numecd.2021.09.005

	Advanced glycation end products via skin autofluorescence as potential marker of carotid atherosclerosis in patients with type 2 diabetes
	Ying, Lingwen 3; Shen, Yun 3; Zhang, Yang 1,2; Wang, Yikun 1; Liu, Yong 1; Yin, Jun 3; Wang, Yufei 3; Yin, Jingrong 3; Zhu, Wei 3; Bao, Yuqian 3
刊名	NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
	2021-11-29
卷号	31
关键词	Advanced glycation end products Carotid atherosclerosis Cardiovascular events Non-invasive Type 2 diabetes
ISSN号	0939-4753
DOI	10.1016/j.numecd.2021.09.005
通讯作者	Wang, Yikun(wyk@aiofm.ac.cn) ; Zhou, Jian(zhoujian@sjtu.edu.cn)
英文摘要	Background and aims: Advanced glycation end products (AGEs) are reported to be correlated with diabetic vascular complications. This study aimed to investigate the association between AGEs and carotid atherosclerosis (CAS) as a surrogate marker of cardiovascular disease (CVD). Methods and results: A total of 1006 patients with type 2 diabetes were included. CAS was defined as the presence of carotid arterial atherosclerotic plaque in any of bilateral carotid artery segments measured by ultrasonography. AGEs were measured by the noninvasive skin autofluorescence method. AGE(age) index was calculated as AGEs x age/100. Patients with CAS showed a significantly higher AGE(age) (P < 0.01), and the prevalence of CAS increased with ascending AGE(age) levels (P for trend < 0.001). Logistic regression analysis revealed that AGE(age) was significantly positively associated with odds of CAS, and the odds ratios of the presence of CAS across quartiles of AGE(age) were 1.00, 3.00 [95% confidence interval (CI) 1.90-4.74], 4.04 (95% CI 2.50-6.53 ) and 4.99 (95% CI 2.97-8.40 ) for the multivariable-adjusted model (P for trend <0.001), respectively. In the fully adjusted model, each 5.0 increase in AGE(age) was associated with a 0.019 mm increment in carotid intima-media thickness. Furthermore, AGE(age) presented an acceptable predictive value for CAS, with an optimal cutoff point of 43.2, and the sensitivity, specificity and area under the curve (AUC) were 74.5% (95% CI 70.7-78.1 %), 61.9% (95%CI 57.2-66.4%) and 0.735 (0.706-0.762), respectively. Conclusion: AGE(age), the noninvasive measurement of AGEs combined with age is a promising approach for triaging patients at high risk of CVDs. (C) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
资助项目	National Key R&D Program of China[2018YFC2000802] ; Shanghai Municipal Educa-tion CommissiondGaofeng Clinical Medicine Grant Sup-port[20161430] ; Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Natural Science Foundation of Anhui Province of China[1908085QH365]
WOS关键词	INTIMA-MEDIA THICKNESS ; LONG-TERM COMPLICATIONS ; RISK ; ENDPRODUCTS ; ASSOCIATION ; PROGRESSION ; MELLITUS ; DISEASE ; PEOPLE
WOS研究方向	Cardiovascular System & Cardiology ; Endocrinology & Metabolism ; Nutrition & Dietetics
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000722579400021
资助机构	National Key R&D Program of China ; Shanghai Municipal Educa-tion CommissiondGaofeng Clinical Medicine Grant Sup-port ; Bureau of International Cooperation, Chinese Academy of Sciences ; Natural Science Foundation of Anhui Province of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126712]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yikun; Zhou, Jian
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Inst Opt & Fine Mech, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet,Shanghai Key Lab Diabet, Shanghai Diabet Inst,Dept Endocrinol & Metab, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Ying, Lingwen,Shen, Yun,Zhang, Yang,et al. Advanced glycation end products via skin autofluorescence as potential marker of carotid atherosclerosis in patients with type 2 diabetes[J]. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,2021,31.
APA	Ying, Lingwen.,Shen, Yun.,Zhang, Yang.,Wang, Yikun.,Liu, Yong.,...&Zhou, Jian.(2021).Advanced glycation end products via skin autofluorescence as potential marker of carotid atherosclerosis in patients with type 2 diabetes.NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,31.
MLA	Ying, Lingwen,et al."Advanced glycation end products via skin autofluorescence as potential marker of carotid atherosclerosis in patients with type 2 diabetes".NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 31(2021).