Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer

doi:10.1016/j.cej.2021.132255

	Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer
	Gan, Yuehao 1,2; Zhang, Jia 1; Lei, Shulai 4; Yan, Miao 3; Xie, Wenteng 1,2; Qi, Xiangyu 3; Wang, Huijuan 2; Xiao, Jianmin 3; Chen, Siyang ; Li, Shujuan
刊名	CHEMICAL ENGINEERING JOURNAL
	2022-02-01
卷号	429
关键词	Gd doping Magnetic iron oxide nanoclusters Atomically precise MRI T-2-weighted contrast agents
ISSN号	1385-8947
DOI	10.1016/j.cej.2021.132255
通讯作者	Zhang, Guilong(glzhang@bzmc.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn)
英文摘要	The use of multi-domain magnetic iron oxide nanoclusters (MMIONs) as Magnetic resonance imaging (MRI) contrast agent is facing problems of strong ferromagnetism and thus weak T-2 contrast ability. The doping of Gd ions holds potential to solve these problems by reducing ferromagnetism and enhancing transverse relaxivity (r(2)), but the exact role of doping in modulating the contrast properties remain unknown. Herein, we prepared a series of atomically precise GdxFe3-xO4 nanoclusters and systematically explored the effect of Gd doping on tuning their morphology, magnetic property, and r(2) value. After the doping of Gd ions, the specific surface area of GdxFe3-xO4 nanoclusters significantly increased, and meanwhile, the magnetic property of GdxFe3-xO4 nanoclusters transformed from ferromagnetism to superparamagnetism, which led to stronger T-2 contrast. Specifically, the highest r(2) value was obtained at 488 mM(-1)s(-1) (7.0 T) for Gd0.072Fe2.928O4 nanocluster, four times higher than that for pristine Fe3O4 (110 mM(-1)s(-1)). For potential applications, we validated the outstanding contrast of Gd0.018Fe2.982O4 nanocluster (r(2) = 481 mM(-1)s(-1) at 7.0 T) to diagnose early orthotopic cancer in mice. This work opens up a new avenue for the development of atomically precise Gd-doped MMIONs as efficient T-2-weighted MRI contrast agents.
资助项目	Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
WOS关键词	TOTAL-ENERGY CALCULATIONS ; IRON-OXIDE NANOPARTICLES ; PROSTATE-CANCER ; PERFORMANCE ; MRI ; DELIVERY ; SIZE
WOS研究方向	Engineering
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000728529900001
资助机构	Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Taishan Scholars Construction Engineering ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126452]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Guilong; Wu, Zhengyan
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Engn & Mat Sci Expt Ctr, Hefei 230026, Peoples R China 3.Binzhou Med Univ, Key Lab Prescript Effect & Clin Evaluat State Adm, Sch Pharm, Yantai 264003, Peoples R China 4.Hubei Univ Arts & Sci, Hubei Key Lab Low Dimens Optoelect Mat & Devices, Xiangyang 441053, Peoples R China
推荐引用方式 GB/T 7714	Gan, Yuehao,Zhang, Jia,Lei, Shulai,et al. Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer[J]. CHEMICAL ENGINEERING JOURNAL,2022,429.
APA	Gan, Yuehao.,Zhang, Jia.,Lei, Shulai.,Yan, Miao.,Xie, Wenteng.,...&Wu, Zhengyan.(2022).Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer.CHEMICAL ENGINEERING JOURNAL,429.
MLA	Gan, Yuehao,et al."Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer".CHEMICAL ENGINEERING JOURNAL 429(2022).