New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect

	New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect
	Xue, Zhaowei; Cao, Zhen; Jin, Ming; Zhang, Xinxin; Wang, Xinrui; Dou, Jianwei; Zhu, Yuhong; Ito, Yoichiro; Guo, Zengjun
刊名	FOOD & FUNCTION
	2021
卷号	12 期号:18
英文摘要	Steroid saponins are the medicinal compounds and nutrition ingredients of medicine food homology (MFH) Dioscorea zingiberensis C. H. Wright (D. zingiberensis) yam. Our phytochemical investigation of the edible rhizomes resulted in 9 new furostanol steroid saponins named dioscins A-I (1-9), together with 11 known steroid saponins. Their chemical structures were elucidated based on spectroscopic and chemical analyses. The new dioscins were evaluated for their anti-inflammatory and beneficial effects against cerebral ischemia reperfusion (I/R) injury on RAW264.7 and PC12 cells in vitro, respectively. Dioscins A, B, and G revealed considerable anti-I/R effect through an anti-inflammatory mechanism based on the decreasing concentration of pro-inflammatory (TNF-alpha and IL-6) and down-regulating the NF-kappa B expression. The present research demonstrated that daily consumption of this yam plant probably prevented the I/R occurrence via the anti-inflammatory property of steroid saponins, and it also enriched the steroid saponin library, providing the possibility to develop MFH-containing steroid saponins into functional foods for maintenance of human health or drugs for the treatment of I/R disease.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/60774]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Xue, Zhaowei,Cao, Zhen,Jin, Ming,et al. New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect[J]. FOOD & FUNCTION,2021,12(18).
APA	Xue, Zhaowei.,Cao, Zhen.,Jin, Ming.,Zhang, Xinxin.,Wang, Xinrui.,...&Guo, Zengjun.(2021).New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect.FOOD & FUNCTION,12(18).
MLA	Xue, Zhaowei,et al."New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect".FOOD & FUNCTION 12.18(2021).