Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury

	Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury
	Meng, Jing; Deng, Kai; Hu, Na; Wang, Honglun
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2021
卷号	186
关键词	Acute lung injury Anti-inflammation Nitraria tangutorum Bobr -derived poly-saccharides
英文摘要	Nitraria tangutorum Bobr. is suggested to be active in immunoregulation and antioxidation. However, the in vivo bioactivity of N. tangutorum Bobr.-derived polysaccharides (NTP) and their anti-inflammatory activity have not been addressed. In the present study, we extracted and purified polysaccharides from N. tangutorum Bobr. and determined their anti-inflammatory activities in vivo. HPGPC, UHPLC/DAD, and NMR analyses identified that the monosaccharide components of NTP were Man, Rha, GalUA, Glu, Gal, and Ara, with relative contents of 3.52%, 15.08%, 10.00%, 26.73%, 38.08%, and 6.59%, respectively. In mice with lipopolysaccharide (LPS)-induced Acute Lung Injury (ALI), NTP treatment attenuated tissue damage, inhibited the production of inflammatory cytokines, and promoted the anti-oxidative response. The supposed mechanism may be via suppressing the Toll -like receptor 4 (TLR4) signaling pathway. In conclusion, our study suggests a protective role of NTP in LPS-induced ALI by inhibiting inflammatory damage.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/60732]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Meng, Jing,Deng, Kai,Hu, Na,et al. Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,186.
APA	Meng, Jing,Deng, Kai,Hu, Na,&Wang, Honglun.(2021).Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,186.
MLA	Meng, Jing,et al."Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 186(2021).