Effect of drag-reducing polymer on blood flow in microchannels

doi:10.1016/j.colsurfb.2021.112212

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Effect of drag-reducing polymer on blood flow in microchannels
	Li, Guanjie 3; Sun, Yang 3; Zheng X(郑旭)2; Choi, Hyoung Jin 1; Zhang, Ke 3
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2022
卷号	209 页码:7
关键词	Hyaluronic acid Red blood cell Velocity Cell-free layer Microcirculation
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2021.112212
通讯作者	Zheng, Xu(zhengxu@lnm.imech.ac.cn) ; Zhang, Ke(zhangke@hit.edu.cn)
英文摘要	Drag-reducing polymers (DRPs) can significantly improve blood circulation when added to blood at a nanomolar concentration, manifesting great potential for application in the biomedical field. In this work, hyaluronic acid (HA) was selected as a natural DRP, and its effects on blood microcirculation at different concentrations, flow rates, and channel geometry were studied in microchannels. The experimental results show that adding a small dose of HA can increase the velocity and shorten the thickness of the cell-free layer (CFL or cell depletion layer (CDL)) near the wall. After considering efficiency, our experiments determined 50 ppm addition of HA to be the most suitable amount for improving blood circulation. Our results demonstrate that HA has high efficiency in improving the circulation of blood flow and shed light on unveiling the mechanism of using natural DRPs to cure some cardiovascular diseases.
分类号	二类/Q1
资助项目	National Natural Science Foundation of China[51603056] ; National Natural Science Foundation of China[11572335] ; Excellent Youth Foundation of Heilongjiang Province of China[YQ2019E020] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program[XDB22040403]
WOS关键词	FREE LAYER WIDTH ; CELL ; MARGINATION ; AGGREGATION ; MICROCIRCULATION ; REDUCTION ; PERFUSION ; OXIDE
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
WOS记录号	WOS:000720947900004
资助机构	National Natural Science Foundation of China ; Excellent Youth Foundation of Heilongjiang Province of China ; CAS Key Research Program of Frontier Sciences ; CAS Strategic Priority Research Program
其他责任者	Zheng, Xu ; Zhang, Ke
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/87996]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Inha Univ, Dept Polymer Sci & Engn, Incheon 22212, South Korea 2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 3.Harbin Inst Technol, MITT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Peoples R China;
推荐引用方式 GB/T 7714	Li, Guanjie,Sun, Yang,Zheng X,et al. Effect of drag-reducing polymer on blood flow in microchannels[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,209:7.
APA	Li, Guanjie,Sun, Yang,郑旭,Choi, Hyoung Jin,&Zhang, Ke.(2022).Effect of drag-reducing polymer on blood flow in microchannels.COLLOIDS AND SURFACES B-BIOINTERFACES,209,7.
MLA	Li, Guanjie,et al."Effect of drag-reducing polymer on blood flow in microchannels".COLLOIDS AND SURFACES B-BIOINTERFACES 209(2022):7.