One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent

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	One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent
	Zhang G(张根)1; Zhang YH(张耀虎)1; Yan JX(闫洁熙)1; Chen R(陈茹)1; Wang SL(王守磊)1; Ma YX(马赟霞)1; Wang R(王锐)1,2
刊名	the Journal of Organic Chemistry
	2012
卷号	77 期号:2 页码:878-888
ISSN号	0022-3263
通讯作者	王锐
英文摘要	Function-oriented design and synthesis of chiral small molecules with novel activity is a key goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging and causing serious diseases, the need for practical routes for the development of new types of antibacterial agents is very urgent. Herein, we present a highly efficient process for the synthesis of optically active pyranocoumarins and 2-amino-4H-chromenes through an organocatalytic Knoevenagel/Michael/cyclization sequence, and the preliminary biological studies of these new heterocyclic compounds revealed potent antibacterial activity. This study provides a novel strategy for further research and development of new types of antibacterial agents effective against human pathogens.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the National Natural Science Foundation of China (No. 90813012;20932003);the Key National S & T Program “Major New Drug Development” of the Ministry of Science and Technology (2012ZX09504001-003)
语种	英语
WOS记录号	WOS:000299238400007
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/3836]
专题	兰州化学物理研究所_OSSO国家重点实验室
作者单位	1.Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang G,Zhang YH,Yan JX,et al. One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent[J]. the Journal of Organic Chemistry,2012,77(2):878-888.
APA	Zhang G.,Zhang YH.,Yan JX.,Chen R.,Wang SL.,...&Wang R.(2012).One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent.the Journal of Organic Chemistry,77(2),878-888.
MLA	Zhang G,et al."One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent".the Journal of Organic Chemistry 77.2(2012):878-888.