L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate

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	L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate
	Zhou JY(周巾英)1,2; Lu GX(吕功煊)1
刊名	Journal of Coordination Chemistry
	2012
卷号	65 期号:20 页码:3580-3591
关键词	ATP Zinc ion L-Arginine Recognition Catalytic hydrolysis
ISSN号	0095-8972
通讯作者	吕功煊
英文摘要	Zn²⁺ can interact with adenosine 5′-triphosphate (ATP) by electrostatic and coordination interactions, and the interaction sites between Zn²⁺ and ATP vary at different pH in the ATP–Zn²⁺ binary system. Non-covalent interactions exist between the carboxyl of arginine (Arg) and Zn²⁺, which led to competition between ATP and Arg to interact with Zn²⁺ in the ATP–Zn²⁺–Arg ternary system. Kinetics studies show that the hydrolysis rate constant of ATP in the ATP–Zn²⁺ binary system was 2.44 × 10⁻²min⁻¹, about 11-fold faster than that (2.27 × 10⁻³min⁻¹) in the ATP–Zn²⁺–Arg ternary system. This may be attributed to coordination interactions between the carboxyl of Arg and Zn²⁺ and the decreased activity of zinc ion toward the phosphate groups via nucleophilic attack. A mechanism that the hydrolysis occurred through an addition–elimination mechanism is proposed.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the 973 Program under Grant No. 2009CB22003
语种	英语
WOS记录号	WOS:000308421300007
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/3901]
专题	兰州化学物理研究所_OSSO国家重点实验室兰州化学物理研究所_ERC国家工程研究中心
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou JY,Lu GX. L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate[J]. Journal of Coordination Chemistry,2012,65(20):3580-3591.
APA	Zhou JY,&Lu GX.(2012).L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate.Journal of Coordination Chemistry,65(20),3580-3591.
MLA	Zhou JY,et al."L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate".Journal of Coordination Chemistry 65.20(2012):3580-3591.