C3-Arylation of indoles with aryl ketones via C-C/C-H activations

doi:10.1039/d1cc03954g

	C3-Arylation of indoles with aryl ketones via C-C/C-H activations
	Guo, Zi-Qiong 1; Xu, Hui 1; Wang, Xing 1,2; Wang, Zhen-Yu 3; Ma, Biao 1; Dai, Hui-Xiong 1,2
刊名	CHEMICAL COMMUNICATIONS
	2021-08-25
页码	4
ISSN号	1359-7345
DOI	10.1039/d1cc03954g
通讯作者	Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.
WOS关键词	REGIOSELECTIVE DIRECT ARYLATION ; CATALYZED C-3 ARYLATION ; METAL-FREE ; PALLADIUM ; FUNCTIONALIZATION ; DERIVATIVES ; COPPER ; LIGHT ; CYCLIZATION ; ALKALOIDS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000692477200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297761]
专题	中国科学院上海药物研究所
通讯作者	Dai, Hui-Xiong
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Guo, Zi-Qiong,Xu, Hui,Wang, Xing,et al. C3-Arylation of indoles with aryl ketones via C-C/C-H activations[J]. CHEMICAL COMMUNICATIONS,2021:4.
APA	Guo, Zi-Qiong,Xu, Hui,Wang, Xing,Wang, Zhen-Yu,Ma, Biao,&Dai, Hui-Xiong.(2021).C3-Arylation of indoles with aryl ketones via C-C/C-H activations.CHEMICAL COMMUNICATIONS,4.
MLA	Guo, Zi-Qiong,et al."C3-Arylation of indoles with aryl ketones via C-C/C-H activations".CHEMICAL COMMUNICATIONS (2021):4.