Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta

doi:10.1016/j.bioorg.2021.105028

	Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta
	Liu, Jiao 1,2; Wu, Meng-Jun 1,3,4; Li, Heng 1; Wang, Hong 3,4; Tang, Wei 1; Gu, Yu-Cheng 5; Li, Xu-Wen 1,2; Guo, Yue-Wei 1,3,4
刊名	BIOORGANIC CHEMISTRY
	2021-09-01
卷号	114 页码:8
关键词	Soft coral Sinularia erecta Casbane Stereochemistry Anti-inflammatory activity
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2021.105028
通讯作者	Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A further systematically chemical investigation of the South China Sea soft coral Sinularia erecta led to the discovery of two rare casbane diterpenoids with an uncommon 8,10-peroxide bridge, sinuereperoxides B (1) and C (2), five new casbanes with other oxygenated patterns (3-7), and seven known casbanes (8-14). The structures and absolute configurations of 1-7 were established by extensive spectroscopic data analyses, X-ray diffraction analysis, and/or quantum chemical calculations. In bioassay, compounds 2, 7, 11 and 12 exhibited considerable anti-inflammatory activity by the inhibition of TNF-alpha release, with IC50 values of 33.8 mu M, 5 mu M, 9.9 mu M and 8 mu M.
资助项目	National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[82022069] ; National Natural Science Foundation of China (NSFC)[42076099] ; National Key Research and Development Program of China[2018YFC0310903] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] ; Syngenta-SIMM-PhD Studentship Project
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000689722000006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297718]
专题	中国科学院上海药物研究所
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 4.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China 5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
推荐引用方式 GB/T 7714	Liu, Jiao,Wu, Meng-Jun,Li, Heng,et al. Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta[J]. BIOORGANIC CHEMISTRY,2021,114:8.
APA	Liu, Jiao.,Wu, Meng-Jun.,Li, Heng.,Wang, Hong.,Tang, Wei.,...&Guo, Yue-Wei.(2021).Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta.BIOORGANIC CHEMISTRY,114,8.
MLA	Liu, Jiao,et al."Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta".BIOORGANIC CHEMISTRY 114(2021):8.