Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1

doi:10.1186/s13045-021-01165-4

	Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1
	Shi,Zhaopeng 1; Gan,Guifang 1; Xu,Xiang 1; Zhang,Jieying 1; Yuan,Yuan 1; Bi,Bo 2; Gao,Xianfu 3; Xu,Pengfei 4; Zeng,Wenbin 4; Li,Jixi 5
刊名	Journal of Hematology & Oncology
	2021-09-25
卷号	14 期号:1
关键词	3-Hydroxyanthronic acid (3-HAA) Kynurenine YY1 DUSP6 Hepatocellular carcinoma (HCC) Tryptophan metabolism
DOI	10.1186/s13045-021-01165-4
通讯作者	Liu,Wen(w2liu@xmu.edu.cn) ; Lin,Shuhai(shuhai@xmu.edu.cn) ; Mi,Jun(jmei@sjtu.edu.cn)
英文摘要	AbstractThe 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKCζ, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S13045-021-01165-4
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297590]
专题	中国科学院上海药物研究所
通讯作者	Liu,Wen; Lin,Shuhai; Mi,Jun
作者单位	1.Shanghai Jiao Tong University School of Medicine; Basic Medical Institute, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Tongren Hospital 2.Shanghai Jiao Tong University School of Medicine; Department of Nuclear Medicine, Rui Jin Hospital 3.Shanghai Profleader Biotech Co., Ltd 4.Central South University; Xiangya School of Pharmaceutical Sciences 5.Fudan University; School of Life Science 6.Chinese Academy of Sciences; CAS Key Laboratory of Receptor Research, Department of Analytical Chemistry, Shanghai Institute of Materia Medica 7.Xiamen University; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology 8.Xiamen University; School of Life Sciences, State Key Laboratory of Cellular Stress Biology
推荐引用方式 GB/T 7714	Shi,Zhaopeng,Gan,Guifang,Xu,Xiang,et al. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1[J]. Journal of Hematology & Oncology,2021,14(1).
APA	Shi,Zhaopeng.,Gan,Guifang.,Xu,Xiang.,Zhang,Jieying.,Yuan,Yuan.,...&Mi,Jun.(2021).Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1.Journal of Hematology & Oncology,14(1).
MLA	Shi,Zhaopeng,et al."Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1".Journal of Hematology & Oncology 14.1(2021).