Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii

doi:10.1021/acs.jnatprod.1c00177

	Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii
	Wang, Xing 1,2,3; Peng, Xia 1,2,4; Tang, Chunping 1,2; Zhou, Shuaizhen 1,2; Ke, Chang-Qiang 1,2; Liu, Yueling 4,5; Yao, Sheng 1,2,3; Ai, Jing 4; Ye, Yang 1,2,3,5
刊名	JOURNAL OF NATURAL PRODUCTS
	2021-05-28
卷号	84 期号:5 页码:1626-1637
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.1c00177
通讯作者	Yao, Sheng(yaosheng@simm.ac.cn) ; Ai, Jing(jai@simm.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要	Fourteen new eudesmane sesquiterpenoids (1, 35, 7-16) and seven known analogues were isolated from the whole plant of Artemisia hedinii. Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were confirmed by X-ray diffraction experiments and TDDFT ECD calculation. Compounds 1-15 were identified as eudesmane acids, which represent a kind of lactone ring-opening eudesmane-type sesquiterpenes with an acetoxyl or a hydroxy group attached to C-9. Compounds 1 and 2, 5 and 6, and 7 and 8 are three pairs of epimers isomerized at C-3, C-5, and C-11, respectively. Compounds 1-9, 11-13, 15-19, and 21 could influence the proinflammatory phenotype of the M1 macrophage. Among them, compounds 5, 8, 9, 12, 16, and 19 consistently exhibited anti-inflammatory effects, as evidenced by downregulating classic pro-inflammatory cytokines TNF-alpha, IL-12, IL-6, and IFN-gamma in LPS-induced primary bone marrow derived M1 macrophages.
资助项目	National Key R&D Program of China[2018YFC1707000] ; National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[21920102003]
WOS关键词	DERIVATIVES ; LACTONES
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000657373100024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297103]
专题	中国科学院上海药物研究所
通讯作者	Yao, Sheng; Ai, Jing; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xing,Peng, Xia,Tang, Chunping,et al. Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(5):1626-1637.
APA	Wang, Xing.,Peng, Xia.,Tang, Chunping.,Zhou, Shuaizhen.,Ke, Chang-Qiang.,...&Ye, Yang.(2021).Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii.JOURNAL OF NATURAL PRODUCTS,84(5),1626-1637.
MLA	Wang, Xing,et al."Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii".JOURNAL OF NATURAL PRODUCTS 84.5(2021):1626-1637.