Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis

doi:10.1016/j.cellimm.2021.104364

	Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis
	Xiang, Caigui 1,2; Liu, Moting 1,2; Lu, Qiukai 1,2; Fan, Chen 1; Lu, Huimin 1,2; Feng, Chunlan 1; Yang, Xiaoqian 1; Li, Heng 1; Tang, Wei 1,2
刊名	CELLULAR IMMUNOLOGY
	2021-07-01
卷号	365 页码:10
关键词	Ulcerative colitis Caffeic acid Toll-like receptors Macrophages
ISSN号	0008-8749
DOI	10.1016/j.cellimm.2021.104364
通讯作者	Li, Heng(liheng@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要	Ulcerative colitis (UC) represents a relapsing and inflammatory bowel disease which is commonly linked with the communications between dysfunction of epithelium and mucosal immune responses. Though caffeic acid (CA) has numerous pharmacological capacities, whether CA demonstrates immunoregulation on the mucosal immune responses remains ill-defined. Herein, the present research demonstrated that CA could dramatically attenuate the mucosal inflammation, as evidenced by improving the disease severity, serum biochemical indexes, mucosal ulcerations, loss of epithelium and crypts, and secretion of inflammatory cytokines in the colonic homogenates and explants culture. Consistently, CA could interfere with the infiltration and function of mononuclear macrophages in the mucosa, MLNs, and spleens of UC. Furthermore, CA exerted direct suppressive effects on the activation of BMDMs upon the exposure of TLRs agonists in vitro. Taken together, CA could attenuate DSSinduced murine UC through interfering with the activation of macrophages, which might provide an alternative therapeutic option for UC.
资助项目	Science & Technology Commission of Shanghai Municipality, China[18431907100] ; Special Research Assistant Project of the Chinese Academy of Sciences
WOS关键词	NF-KAPPA-B ; PHENETHYL ESTER ; IN-VIVO ; APOPTOSIS ; DISEASE ; BARRIER ; CELLS ; MAPK
WOS研究方向	Cell Biology ; Immunology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000656866800005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297021]
专题	中国科学院上海药物研究所
通讯作者	Li, Heng; Tang, Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xiang, Caigui,Liu, Moting,Lu, Qiukai,et al. Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis[J]. CELLULAR IMMUNOLOGY,2021,365:10.
APA	Xiang, Caigui.,Liu, Moting.,Lu, Qiukai.,Fan, Chen.,Lu, Huimin.,...&Tang, Wei.(2021).Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis.CELLULAR IMMUNOLOGY,365,10.
MLA	Xiang, Caigui,et al."Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis".CELLULAR IMMUNOLOGY 365(2021):10.