Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature

doi:10.1016/j.fitote.2021.104919

	Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature
	Sui, Jian 1,2,3; Tang, Chunping 1,2; Ke, Chang-Qiang 1,2; Ye, Yang 1,2,3,4
刊名	FITOTERAPIA
	2021-07-01
卷号	152 页码:7
关键词	Bletilla striata Phenanthrene bibenzyl atropisomer LC-CD Bletistriatins A-D Bi(9 10-dihydro)phenanthrene
ISSN号	0367-326X
DOI	10.1016/j.fitote.2021.104919
通讯作者	Ye, Yang(yye@simm.ac.cn)
英文摘要	Four pairs of undescribed racemic bi(9,10-dihydro) phenanthrene and phenanthrene/bibenzyl atropisomers, bletistriatins A-D (1 & ndash;4), along with 22 known compounds were isolated from the rhizomes of Bletilla striata. These dimeric derivatives were constructed through direct C & ndash;C connection or an oxygen bridge. The structures of new compounds were fully established by extensive analysis of MS, and 1D and 2D NMR spectroscopic data. Owing to sterically hindered rotation around the biaryl axis, these dimeric 9,10-dihydrophenanthrene derivatives can exist as a pair of enantiomers, but were isolated as racemates. Their racemates were separated to yield enantiomerically pure compounds by HPLC on an optically active stationary phase, and were stereochemically characterized on-line by circular dichroism (CD) spectroscopy (LC-CD coupling). Some isolates were evaluated for cytotoxicity against human cancer cell lines HL-60 and A549. Compounds 13, 17, and 20 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.56 to 8.67 mu M.
资助项目	National Natural Science Foundation of China[21920102003] ; Science and Technology Commission of Shanghai Municipality[20430780300]
WOS关键词	CHEMICAL-CONSTITUENTS ; PHENANTHRENES ; BIPHENANTHRENES ; TUBERS ; PLANT
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000663829000010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296858]
专题	中国科学院上海药物研究所
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Sui, Jian,Tang, Chunping,Ke, Chang-Qiang,et al. Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature[J]. FITOTERAPIA,2021,152:7.
APA	Sui, Jian,Tang, Chunping,Ke, Chang-Qiang,&Ye, Yang.(2021).Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature.FITOTERAPIA,152,7.
MLA	Sui, Jian,et al."Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature".FITOTERAPIA 152(2021):7.