Supramolecular Antagonists Promote Mitochondrial Dysfunction

doi:10.1021/acs.nanolett.1c01469

	Supramolecular Antagonists Promote Mitochondrial Dysfunction
	Li, Mingming 1; Song, Yanqiu 1; Song, Na 1; Wu, Guangyao 1; Zhou, Hao 2; Long, Jiafu 2; Zhang, Pengcheng 3,4; Shi, Linqi 1; Yu, Zhilin 1
刊名	NANO LETTERS
	2021-07-14
卷号	21 期号:13 页码:5730-5737
关键词	Self-Assembly Peptides Drug Delivery Mitochondrion-Targeting Antagonists
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.1c01469
通讯作者	Yu, Zhilin(yzh026@nankai.edu.cn)
英文摘要	Mitochondrion-targeting therapy exhibits great potential in cancer therapy but significantly suffers from limited therapeutic efficiency. Here we report on mitochondrion-targeting supramolecular antagonist-inducing tumor cell death via simultaneously promoting cellular apoptosis and preventing survival. The supramolecular antagonist was created via coassembly of a mitochondrion-targeting pentapeptide with its two derivatives functionalized with a BH3 domain or the drug camptothecin (CPT). While drug CPT released from the antagonist induced cellular apoptosis via decreasing the mitochondrial membrane potential, the BH3 domain prevented cellular survival through facilitating the association between the supramolecular antagonists and antiapoptotic proteins, thereby initiating mitochondrial permeabilization. Both in vitro and in vivo studies confirmed the combinatorial therapeutic effect arising from the BH3 domain and CPT drug within the supramolecular antagonist on cell death and thereby inhibiting tumor growth. Our findings demonstrate an efficient combinatorial mechanism for mitochondrial dysfunction, thus potentially serving as novel organelle-targeting medicines.
资助项目	Fundamental Research Funds for the Central Universities (Nankai University)[63213070] ; National Natural Science Foundation of China[21774065] ; National Natural Science Foundation of China[51933006] ; National Natural Science Foundation of China[81972903]
WOS关键词	DRUG-DELIVERY ; PEPTIDE ; AFFINITY ; PROBES ; TUMOR
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000674354200038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296763]
专题	中国科学院上海药物研究所
通讯作者	Yu, Zhilin
作者单位	1.Nankai Univ, Coll Chem, Inst Polymer Chem, Key Lab Funct Polymer Mat,Minist Educ,State Key L, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Life Sci, Key Lab Med Chem Biol, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Mingming,Song, Yanqiu,Song, Na,et al. Supramolecular Antagonists Promote Mitochondrial Dysfunction[J]. NANO LETTERS,2021,21(13):5730-5737.
APA	Li, Mingming.,Song, Yanqiu.,Song, Na.,Wu, Guangyao.,Zhou, Hao.,...&Yu, Zhilin.(2021).Supramolecular Antagonists Promote Mitochondrial Dysfunction.NANO LETTERS,21(13),5730-5737.
MLA	Li, Mingming,et al."Supramolecular Antagonists Promote Mitochondrial Dysfunction".NANO LETTERS 21.13(2021):5730-5737.