Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF

doi:10.3389/fgene.2021.668702

	Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF
	Zhou, Guofeng 5; Sun, Shaoyan 4; Yuan, Qiuyue 2,3; Zhang, Run 4; Jiang, Ping 5; Li, Guangyu 3; Wang, Yong 2,3; Li, Xiao 1
刊名	FRONTIERS IN GENETICS
	2021-07-08
卷号	12 页码:14
关键词	heart failure with preserved ejection fraction differentially expressed genes differentially correlated gene pairs differential network molecular docking
DOI	10.3389/fgene.2021.668702
英文摘要	Heart failure with preserved ejection fraction (HFpEF) is a complex disease characterized by dysfunctions in the heart, adipose tissue, and cerebral arteries. The elucidation of the interactions between these three tissues in HFpEF will improve our understanding of the mechanism of HFpEF. In this study, we propose a multilevel comparative framework based on differentially expressed genes (DEGs) and differentially correlated gene pairs (DCGs) to investigate the shared and unique pathological features among the three tissues in HFpEF. At the network level, functional enrichment analysis revealed that the networks of the heart, adipose tissue, and cerebral arteries were enriched in the cell cycle and immune response. The networks of the heart and adipose tissues were enriched in hemostasis, G-protein coupled receptor (GPCR) ligand, and cancer-related pathway. The heart-specific networks were enriched in the inflammatory response and cardiac hypertrophy, while the adipose-tissue-specific networks were enriched in the response to peptides and regulation of cell adhesion. The cerebral-artery-specific networks were enriched in gene expression (transcription). At the module and gene levels, 5 housekeeping DEGs, 2 housekeeping DCGs, 6 modules of merged protein-protein interaction network, 5 tissue-specific hub genes, and 20 shared hub genes were identified through comparative analysis of tissue pairs. Furthermore, the therapeutic drugs for HFpEF-targeting these genes were examined using molecular docking. The combination of multitissue and multilevel comparative frameworks is a potential strategy for the discovery of effective therapy and personalized medicine for HFpEF.
资助项目	Chinese National Natural Science Foundations[81673970] ; Chinese National Natural Science Foundations[11901272] ; National Key Research and Development Program of China[2020YFA0712402]
WOS研究方向	Genetics & Heredity
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000675498900001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/58950]
专题	中国科学院数学与系统科学研究院
通讯作者	Sun, Shaoyan; Li, Xiao
作者单位	1.Shandong Univ Tradit Chinese Med, Dept Cardiovasc, Affiliated Hosp, Jinan, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, CEMS, NCMIS, Beijing, Peoples R China 4.Ludong Univ, Sch Math & Stat, Yantai, Peoples R China 5.Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Guofeng,Sun, Shaoyan,Yuan, Qiuyue,et al. Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF[J]. FRONTIERS IN GENETICS,2021,12:14.
APA	Zhou, Guofeng.,Sun, Shaoyan.,Yuan, Qiuyue.,Zhang, Run.,Jiang, Ping.,...&Li, Xiao.(2021).Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF.FRONTIERS IN GENETICS,12,14.
MLA	Zhou, Guofeng,et al."Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF".FRONTIERS IN GENETICS 12(2021):14.