Mexicanolide-type limonoids from the twigs and leaves of Cipadessa baccifera | |
Cao, Dong-Hua; Liao, Shang-Gao; Sun, Peng5; Xiao, Yi-Dian; Xiao, Chun-Fen; Hu, Hua-Bin; Weckwerth, Wolfram2,3; Xu, You-Kai | |
刊名 | PHYTOCHEMISTRY |
2020 | |
卷号 | 177期号:x页码:- |
关键词 | Cipadessa baccifera Meliaceae Mexicanolide-type limonoid Structure elucidation Biological activity |
ISSN号 | 0031-9422 |
DOI | 10.1016/j.phytochem.2020.112449 |
英文摘要 | Twelve previously undescribed mexicanolide-type limonoids, including two pairs of isomers, together with seven known analogues were isolated from the twigs and leaves of Cipadessa baccifera. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Structural variations mainly occurred at the attachment of C-3 and the carbon residues linked to C-17. 21-deoxo-23-oxofebrifugin A and 3-O-detigloyl-3-O-isobutyryl-21-deoxo-23-oxofebrifugin A are two rare naturally occurring mexicanolide-type limonoids bearing an alpha,beta-unsaturated-gamma-lactone motif at C-17. Moreover, cipaferen R is the first degraded tetranortriterpenoid derivative featuring an unique acetyl group at C-17. Some isolated compounds were evaluated for nematicidal, antifungal, cytotoxic (against five human cancer cell lines), and acetylcholinesterase inhibitory activities. No nematicidal and antifungal activities were observed, yet 3-O-detigloyl-3-O-isobutyrylfebrifugin A, febrifugin A, febrifugin, and khaysin T exhibited moderate cytotoxic activity against the tested cells with IC50 values ranging from 18.56 +/- 0.27 to 38.00 +/- 0.85 mu M, and 3-O-detigloyl-3-O-isobutyrylfebrifugin A, granatumin E, khaysin T, and 2'S-cipadesin A showed moderate inhibitory activities against acetylcholinesterase (AChE) at 50 mu M. |
学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
语种 | 英语 |
WOS记录号 | WOS:000558604600022 |
内容类型 | 期刊论文 |
源URL | [http://ir.xtbg.org.cn/handle/353005/11779] |
专题 | 西双版纳热带植物园_民族植物学研究组 |
作者单位 | 1.Guizhou Med Univ, Sch Pharm, Guiyang 550025, Guizhou, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China 3.Univ Vienna, Dept Ecogen & Syst Biol, Althanstr 14, A-1090 Vienna, Austria 4.Univ Vienna, Vienna Metabol Ctr VIME, Althanstr 14, A-1090 Vienna, Austria 5.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550025, Guizhou, Peoples R China 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Cao, Dong-Hua,Liao, Shang-Gao,Sun, Peng,et al. Mexicanolide-type limonoids from the twigs and leaves of Cipadessa baccifera[J]. PHYTOCHEMISTRY,2020,177(x):-. |
APA | Cao, Dong-Hua.,Liao, Shang-Gao.,Sun, Peng.,Xiao, Yi-Dian.,Xiao, Chun-Fen.,...&Xu, You-Kai.(2020).Mexicanolide-type limonoids from the twigs and leaves of Cipadessa baccifera.PHYTOCHEMISTRY,177(x),-. |
MLA | Cao, Dong-Hua,et al."Mexicanolide-type limonoids from the twigs and leaves of Cipadessa baccifera".PHYTOCHEMISTRY 177.x(2020):-. |
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