Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer

doi:10.1039/d0qm00786b

CORC > 金属研究所 > 中国科学院金属研究所

	Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer
	Bao, Zhihong 1; Li, Kexin 1; Hou, Peipei 2; Xiao, Ru 3; Yuan, Yue 1; Sun, Zhenhua 3
刊名	MATERIALS CHEMISTRY FRONTIERS
	2021-02-21
卷号	5 期号:4 页码:1632-1654
DOI	10.1039/d0qm00786b
通讯作者	Bao, Zhihong(baozhihong@syphu.edu.cn) ; Sun, Zhenhua(zhsun@imr.ac.cn)
英文摘要	Phototherapy, a light-induced method, involves photodynamic therapy (PDT) and photothermal therapy (PTT). Recently, PDT and PTT have attracted significant attention due to their non-invasiveness, minimal side effects and high spatial selectivity upon localized irradiation at the tumor sites. Owing to the unique characters of nanoscale metal-organic frameworks (nMOFs) associated with excellent loading, versatile surface chemistries, enhanced permeability and retention effect and biodegradability, nMOFs are very suitable for biomedical applications. Importantly, the periodic porous structure of nMOFs can effectively avoid the self-aggregation and self-quenching of photosensitizers in PDT, and enhance the photothermal responses and heat stability of photothermal agents in PTT. These specific merits of the nMOFs have enabled them as an ideal platform for cancer phototherapy. This review mainly discusses and summarizes the advancement of MOF-based nanocomposites as a therapeutic platform for cancer phototherapy or synergistic phototherapy within the last five years. In addition, this review also focused on the interrelationship between the structure and application of MOF-based composites. The remaining challenges and future opportunities in this field are also highlighted.
资助项目	Natural Science Foundation of Liaoning Province of China[2020-MS-188] ; Research Project of Science and Technology of the Department of Education of Liaoning Province[2019LJC01] ; Project of Shenyang Key Laboratory of Functional Drug Carrier Materials[19-110-4-08] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[Y201942]
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000621097700006
资助机构	Natural Science Foundation of Liaoning Province of China ; Research Project of Science and Technology of the Department of Education of Liaoning Province ; Project of Shenyang Key Laboratory of Functional Drug Carrier Materials ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/160959]
专题	金属研究所_中国科学院金属研究所
通讯作者	Bao, Zhihong; Sun, Zhenhua
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang Key Lab Funct Drug Carrier Mat, Shenyang 110016, Peoples R China 2.China Med Univ, Peoples Hosp Liaoning Prov, Peoples Hosp, Dept Cardiol, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Bao, Zhihong,Li, Kexin,Hou, Peipei,et al. Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer[J]. MATERIALS CHEMISTRY FRONTIERS,2021,5(4):1632-1654.
APA	Bao, Zhihong,Li, Kexin,Hou, Peipei,Xiao, Ru,Yuan, Yue,&Sun, Zhenhua.(2021).Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer.MATERIALS CHEMISTRY FRONTIERS,5(4),1632-1654.
MLA	Bao, Zhihong,et al."Nanoscale metal-organic framework composites for phototherapy and synergistic therapy of cancer".MATERIALS CHEMISTRY FRONTIERS 5.4(2021):1632-1654.