Highly dynamic transcriptional reprogramming and shorter isoform shifts under acute stresses during biological invasions

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Highly dynamic transcriptional reprogramming and shorter isoform shifts under acute stresses during biological invasions
	Huang, Xuena; Zhan, Aibin
刊名	RNA BIOLOGY
	2020-03-04
卷号	18 期号:3 页码:340-353
关键词	Biological invasion gene expression plasticity alternative splicing environmental challenge invasive ascidians
ISSN号	1547-6286
英文摘要	Phenotypic plasticity has been increasingly recognized for its importance in adaptation to novel environments, and initial rapid plastic response to acute stresses usually serves as the stepping stone for future adaptation. Differential gene expression and alternative splicing have been proposed as two underlying mechanisms for rapid plastic response to environmental stresses. Here, we used an invasive model species,Ciona savignyi, to investigate the temporary plastic changes under temperature stresses on gene expression and alternative splicing. Our results revealed rapid and highly dynamic gene expression reprogramming and alternative splicing switch under acute stresses. Distinct transcriptional response profiles were triggered by two types of temperature stresses, showing resilience recovery and increasing divergence under heat and cold challenges, respectively. Interestingly, alternative exons were more inclined to be skipped under both heat and cold stresses, leading to shorter isoforms but with maintained Open Reading Frames (ORFs). Although similar response patterns were observed between differential gene expression and alternative splicing, low overlap between Differentially Expressed Genes (DEGs) and Differentially Alternative Spliced Genes (DASGs) suggests that distinct gene sets and associated functions should be involved in temperature challenges. Thus, alternative splicing should offer an additional layer of plastic response to environmental challenges. Finally, we identified key plastic genes involved in both gene expression regulation and alternative splicing. The results obtained here shed light on adaptation and accommodation mechanisms during biological invasions, particularly for acute environmental changes at early stages of biological invasions such as transport and introduction.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/45170]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Huang, Xuena,Zhan, Aibin. Highly dynamic transcriptional reprogramming and shorter isoform shifts under acute stresses during biological invasions[J]. RNA BIOLOGY,2020,18(3):340-353.
APA	Huang, Xuena,&Zhan, Aibin.(2020).Highly dynamic transcriptional reprogramming and shorter isoform shifts under acute stresses during biological invasions.RNA BIOLOGY,18(3),340-353.
MLA	Huang, Xuena,et al."Highly dynamic transcriptional reprogramming and shorter isoform shifts under acute stresses during biological invasions".RNA BIOLOGY 18.3(2020):340-353.