TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells
	Shan, Anqi; Leng, Ling; Li, Jing; Luo, Xiu-mei; Fan, Ya-jiao; Yang, Qiaoyun; Xie, Qun-hui; Chen, Yang-sheng; Ni, Chun-sheng; Guo, Li-ming
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2020-11-05
卷号	398 页码:1-10
关键词	Coexposure Antagonism AhR Migration Invasion
ISSN号	0304-3894
英文摘要	Evidence has shown that the activation of AhR (aryl hydrocarbon receptor) can promote cancer cell metastasis. However, limited studies have been carried out on mixed exposure to endocrine-disrupting chemicals (EDCs), especially in human breast cancer. Therefore, using MCF7 human breast cancer cells, we investigated the effects of coexposure to MEHP (mono 2-ethylhexyl phthalate) and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on cell migration and invasion, as well as the roles of AhR and the MMP/slug pathway. Our data suggest that MEHP or TCDD can induce migration and invasion in MCF7 cells, and the promotion is partly AhR dependent. We also observed that MEHP antagonized TCDD to reduce AhR-mediated CYP1A1 expression. Subsequently, we revealed that MEHP recruited AhR to dioxin response element (DRE) sequences and decreased TCDD-induced AhR-DRE binding in CYP1A1 genes. Overall, MEHP is a potential AHR agonist, capable of decreasing TCDD-induced AhRDRE binding in CYP1A1 genes. The antagonizing effect of coexposure led to the inhibition of the epithelial-mesenchymal transition (EMT) in MCF7 cells. Our study provides new evidence for the potential mechanisms involved in EDCs exposure and their interactions in EMT.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44817]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Shan, Anqi,Leng, Ling,Li, Jing,et al. TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,398:1-10.
APA	Shan, Anqi.,Leng, Ling.,Li, Jing.,Luo, Xiu-mei.,Fan, Ya-jiao.,...&Tang, Nai-jun.(2020).TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells.JOURNAL OF HAZARDOUS MATERIALS,398,1-10.
MLA	Shan, Anqi,et al."TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells".JOURNAL OF HAZARDOUS MATERIALS 398(2020):1-10.